Antibody

TARDPB /TDP-43 (2E2-D3)

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Clonality: monoclonal
Host: Mouse
Isotype: IgG1,κ
Source: Abnova Corporation
Cat# H00023435-M01
References:
Steinacker, 2008
Zhang, 2008, epitope mapping.
Winton, 2008
Formulation: liquid, PBS
Reactivity:
Reacts in: Human
<em>not</em> mouse or rat

Immunogen/Epitope

immunogen = TARDBP (AAH01487, aa 1 ~261) full length recombinant protein with GST tag. (epitope at aa 205-222)

Specificity

recognizes aa 205–222 of human TDP-43, correspond. to a part of the second RNA recognition motif (RRM2);also recognizes 25 kDa C-terminal fragments

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References

Paper Citations

  1. Steinacker P, Hendrich C, Sperfeld AD, Jesse S, von Arnim CA, Lehnert S, Pabst A, Uttner I, Tumani H, Lee VM, Trojanowski JQ, Kretzschmar HA, Ludolph A, Neumann M, Otto M. TDP-43 in cerebrospinal fluid of patients with frontotemporal lobar degeneration and amyotrophic lateral sclerosis. Arch Neurol. 2008 Nov;65(11):1481-7. PubMed.
  2. Zhang HX, Tanji K, Mori F, Wakabayashi K. Epitope mapping of 2E2-D3, a monoclonal antibody directed against human TDP-43. Neurosci Lett. 2008 Mar 28;434(2):170-4. PubMed.
  3. Winton MJ, Igaz LM, Wong MM, Kwong LK, Trojanowski JQ, Lee VM. Disturbance of nuclear and cytoplasmic TAR DNA-binding protein (TDP-43) induces disease-like redistribution, sequestration, and aggregate formation. J Biol Chem. 2008 May 9;283(19):13302-9. PubMed.

Further Reading

No Available Further Reading