Antibody

Tau, truncated, cleavage site 421/422 (Tau-C3)

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Clonality: monoclonal
Host: Mouse
Isotype: IgG1,κ
Source: Biosource Invitrogen
Cat# AHB0061
Reference:
Spires-Jones, 2008
Formulation: affinity purified ascites, PBS, BSA, azide, unconj.
Reactivity:
Reacts in: Human, Mouse, Rat
others not tested

Immunogen/Epitope

immunogen = KLH- CSSTGSIDMVD, corresp. to the C-terminus of tau truncated at Asp421

Specificity

recognizes tau when truncated at Asp421; no reaction with full-length tau, or with tau truncated at Glu391 or Ala429

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References

Paper Citations

  1. Spires-Jones TL, de Calignon A, Matsui T, Zehr C, Pitstick R, Wu HY, Osetek JD, Jones PB, Bacskai BJ, Feany MB, Carlson GA, Ashe KH, Lewis J, Hyman BT. In vivo imaging reveals dissociation between caspase activation and acute neuronal death in tangle-bearing neurons. J Neurosci. 2008 Jan 23;28(4):862-7. PubMed.

Further Reading

No Available Further Reading