Petit A, Bihel F, Alvès da Costa C, Pourquié O, Checler F, Kraus JL. New protease inhibitors prevent gamma-secretase-mediated production of Abeta40/42 without affecting Notch cleavage. Nat Cell Biol. 2001 May;3(5):507-11. PubMed.

Comments

- Hiroshi Mori
  Osaka City University Medical School
- Posted: 04 Jul 2002
It is an unexpected finding of the occurrence of an inhibitor to block APP-gamma secretase but not Notch processing. Although we do not know the physiological function of the soluble secreted amyloid protein, it is now potent to exclusively regulate APP metabolism.

View all comments by Hiroshi Mori

Make a Comment

To make a comment you must login or register.

Paper

Tools

Comments

Make a Comment

This paper appears in the following:

News