Walsh DM, Fadeeva JV, LaVoie MJ, Paliga K, Eggert S, Kimberly WT, Wasco W, Selkoe DJ. gamma-Secretase cleavage and binding to FE65 regulate the nuclear translocation of the intracellular C-terminal domain (ICD) of the APP family of proteins. Biochemistry. 2003 Jun 10;42(22):6664-73. PubMed.

Recommends

Please login to recommend the paper.

Comments

  1. The statement in the paper, "any strategy aimed at altering APP proteolysis will have to take into account possible effects on signaling by APLP1 and 2," sounds quite logical and resonable. One remaining major remainig question is what the biological functions of the seemingly constitutively generated ICDs of APP and APLPs are.

    View all comments by Takaomi Saido

Make a Comment

To make a comment you must login or register.