Hartmann D, De Strooper B, Serneels L, Craessaerts K, Herreman A, Annaert W, Umans L, Lübke T, Lena Illert A, Von Figura K, Saftig P. The disintegrin/metalloprotease ADAM 10 is essential for Notch signalling but not for alpha-secretase activity in fibroblasts. Hum Mol Genet. 2002 Oct 1;11(21):2615-24. PubMed.
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Convincing evidence that ADAM10 is requred for notch S2 cleavage but unclear how it may be involved in APP alpha secretase cleavage. Ultimately, alpha-secretase may indeed be a collection of protease rather than one, could gamma be the same??
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