Deng HX, Shi Y, Yang Y, Ahmeti KB, Miller N, Huang C, Cheng L, Zhai H, Deng S, Nuytemans K, Corbett NJ, Kim MJ, Deng H, Tang B, Yang Z, Xu Y, Chan P, Huang B, Gao XP, Song Z, Liu Z, Fecto F, Siddique N, Foroud T, Jankovic J, Ghetti B, Nicholson DA, Krainc D, Melen O, Vance JM, Pericak-Vance MA, Ma YC, Rajput AH, Siddique T. Identification of TMEM230 mutations in familial Parkinson's disease. Nat Genet. 2016 Jul;48(7):733-9. Epub 2016 Jun 6 PubMed.

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  1. We have assessed the evidence for TMEM230 mutations as a cause of Parkinson's disease, and question the validity of the original work by Deng and colleagues, 2016. We conclude 'TMEM230 is NOT a gene for Parkinson's disease' (see bioRχiv for details).

    View all comments by Matthew M J Farrer

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