Cordeiro MF, Guo L, Luong V, Harding G, Wang W, Jones HE, Moss SE, Sillito AM, Fitzke FW. Real-time imaging of single nerve cell apoptosis in retinal neurodegeneration. Proc Natl Acad Sci U S A. 2004 Sep 7;101(36):13352-6. PubMed.
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King Edward Medical University Lahore, Pakistan
This is a good effort, and I think that it would be important in the field of retinal disease. It is clear that the retinal and hippocampal neurons are much different. Being sensitive to light, the retinal neurons have different physiological levels. Retinal neurons are loaded with vitamin A, and the areas degenerated in Alzheimer's disease are found to be deficient in this. On the other hand, it is difficult to study a neuron, with its physiological relations and functions, in vivo. So it is important to investigate the progression of pathways of neuronal degeneration. This goal is supported by the present research material. I think that NOS-3 (nitric oxide synthase 3) has a prominent role during apoptotic development in AD. This needs to be studied. The present article could be much more helpful for the patients of retinal detachment.
References:
de la Monte SM, Chiche J, von dem Bussche A, Sanyal S, Lahousse SA, Janssens SP, Bloch KD. Nitric oxide synthase-3 overexpression causes apoptosis and impairs neuronal mitochondrial function: relevance to Alzheimer's-type neurodegeneration. Lab Invest. 2003 Feb;83(2):287-98. PubMed.
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