Olsson A, Vanderstichele H, Andreasen N, De Meyer G, Wallin A, Holmberg B, Rosengren L, Vanmechelen E, Blennow K. Simultaneous measurement of beta-amyloid(1-42), total tau, and phosphorylated tau (Thr181) in cerebrospinal fluid by the xMAP technology. Clin Chem. 2005 Feb;51(2):336-45. Epub 2004 Nov 24 PubMed.

AlzBiomarker Database

Meta-Analysis

Curated Study Data

Biomarker
(Source)		 Cohort
(N)		 Measurement
Mean ± SD		 Method;
Assay Name;
Manufacturer		 Diagnostic
Criteria
tau-p181
(CSF)		 AD
(78)		 117 ± 56.8
pg/mL §		 xMAP;
AlzBio3;
Innogenetics		 McKhann et al., 1984
tau-p181
(CSF)		 CTRL-
CNC
(53)		 78.3 ± 37.6
pg/mL §		 xMAP;
AlzBio3;
Innogenetics
tau-p181
(CSF)		 DLB
(15)		 53 ± 14.3
pg/mL §		 xMAP;
AlzBio3;
Innogenetics		 McKeith et al., 1996
tau-p181
(CSF)		 FTD
(16)		 68.5 ± 28
pg/mL §		 xMAP;
AlzBio3;
Innogenetics		 1994
tau-p181
(CSF)		 MSA
(36)		 38.9 ± 18.8
pg/mL §		 xMAP;
AlzBio3;
Innogenetics		 Quinn, 1989
tau-p181
(CSF)		 PD
(46)		 52.6 ± 24.6
pg/mL §		 xMAP;
AlzBio3;
Innogenetics		 Hughes et al., 1992
tau-p181
(CSF)		 PSP
(15)		 44.7 ± 13.2
pg/mL §		 xMAP;
AlzBio3;
Innogenetics		 Golbe and , 1992
tau-total
(CSF)		 AD
(78)		 737 ± 359
pg/mL §		 xMAP;
AlzBio3;
Innogenetics		 McKhann et al., 1984
tau-total
(CSF)		 CTRL-
CNC
(53)		 358 ± 159
pg/mL §		 xMAP;
AlzBio3;
Innogenetics
tau-total
(CSF)		 DLB
(15)		 400 ± 258
pg/mL §		 xMAP;
AlzBio3;
Innogenetics		 McKeith et al., 1996
tau-total
(CSF)		 FTD
(16)		 448 ± 392
pg/mL §		 xMAP;
AlzBio3;
Innogenetics		 1994
tau-total
(CSF)		 MSA
(36)		 244 ± 152
pg/mL §		 xMAP;
AlzBio3;
Innogenetics		 Quinn, 1989
tau-total
(CSF)		 PD
(46)		 196 ± 84.8
pg/mL §		 xMAP;
AlzBio3;
Innogenetics		 Hughes et al., 1992
tau-total
(CSF)		 PSP
(15)		 224 ± 65.3
pg/mL §		 xMAP;
AlzBio3;
Innogenetics		 Golbe and , 1992

§ Data supplied to Alzforum by author

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AlzBiomarker

  1. AD vs CTRL : tau-p181 (CSF)
  2. CTRL vs AD : tau-p181 (CSF)
  3. DLB vs AD : tau-p181 (CSF)
  4. FTD vs AD : tau-p181 (CSF)
  5. MSA vs AD : tau-p181 (CSF)
  6. PD vs AD : tau-p181 (CSF)
  7. PSP vs AD : tau-p181 (CSF)
  8. AD vs CTRL : tau-total (CSF)
  9. CTRL vs AD : tau-total (CSF)
  10. DLB vs AD : tau-total (CSF)
  11. FTD vs AD : tau-total (CSF)
  12. MSA vs AD : tau-total (CSF)
  13. PD vs AD : tau-total (CSF)
  14. PSP vs AD : tau-total (CSF)