Clioquinol Trial Postmortem: Does Blocking Metal-Aβ Interactions Work?

WEBINAR 2004-01-15 Ashley Bush led this live discussion on 15 January 2004. Readers are invited to submit additional comments by using our Comments form at the bottom of the page. Transcript: Ashley Bush led this live discussion on 15 January 2004. Participants: Ashley Bush

Novel Substrates for BACE1 Beg the Question: What's the Biological Function of β-Secretase?

WEBINAR 2003-12-17 Stefan Lichtenthaler led this live discussion on 17 December 2003. Readers are invited to submit additional comments by using our Comments form at the bottom of the page. Transcript: Stefan Lichtenthaler led this live discussion on 17 December 2003. Parti

Is Alzheimer's an Autoimmune Disease?

WEBINAR 2003-12-04 Michael R. D'Andrea led this live discussion on 4 December 2003. Readers are invited to submit additional comments by using our Comments form at the bottom of the page. Transcript: Mike D'Andrea led this live discussion on 4 December 2003. Parti

BDNF and Alzheimer's Disease—What's the Connection?

WEBINAR 2003-11-25 Nicole C. Berchtold and Carl W. Cotman led this live discussion on 25 November 2003. Readers are invited to submit additional comments by using our Comments form at the bottom of the page. Transcript: Nicole C. Berchtold and Carl W. Cotman led this live d

Alzheimer's: A Triple Whammy. Why are So Many Neurodegenerative Diseases Single, Double, or Triple Amyloidoses?

WEBINAR 2003-10-22 John Q. Trojanowski and Mark P. Mattson discussed the major commonality between many neurodegenerative diseases. Otherwise vastly different conditions that run the gamut from Alzheimer's, Parkinson's, Huntington's, ALS, to prion disorders,

Therapeutic Nihilism: Widespread Yet Passé? AD Acetylcholinesterase Inhibitors Are Better Than Their Reputation

WEBINAR 2003-10-14 John C. Morris, Murray Raskind, and Martin Farlow led this live discussion on 14 October 2003. Readers are invited to submit additional comments by using our Comments form at the bottom of the page. Transcript: John C. Morris, M.D. led this live discussio

Are Neurons Just Too Laissez-Faire about Repair?

WEBINAR 2003-07-24 Thierry Nouspikel led this live discussion on 14 July 2003. Readers are invited to submit additional comments by using our Comments form at the bottom of the page. Transcript: Dr. Thierry Nouspikel led this live discussion on 14 July 2003. Moderated by Dr

How Does Excess Aβ Leave the Brain, How Does It Get In, And Can We Trap It Outside?

WEBINAR 2003-06-23 Berislav Zlokovic led this live discussion on 23 June 2003. Readers are invited to submit additional comments by using our Comments form at the bottom of the page. Transcript: Berislav Zlokovic, University of Rochester, led this live discussion on 23 June

Axonal Transport Hypothesis Moves On to Implicate Presenilin

WEBINAR 2003-06-17 This live discussion is an update of last year's initial Live Discussion of axonal transport as an underlying factor in neurodegeneration. Jorge Busciglio and Scott Brady led this live discussion on 17 June 2003. Readers are invited to submit additio

Cholinergic Plasticity in Hippocampus of Individuals with Mild Cognitive Impairment: Correlation with Alzheimer's Neuropathology

WEBINAR 2003-05-19 This Live Journal Discussion is the first in a series of upcoming discussions of selected articles in the Journal of Alzheimer's Disease, which is making the full text (.pdf) of these papers available to Alzforum for this purpose. Paper du Jour: Ikon

Protein Folding and Neurodegeneration: Biophysics to the Rescue?

WEBINAR 2003-04-30 David Teplow led this live discussion on 30 April 2003. Readers are invited to submit additional comments by using our Comments form at the bottom of the page.   See also David Thirumalai's Emerging Ideas on the Molecular Basis of Protein and Peptide

RNAi in Neurodegenerative Diseases—What's the Therapeutic Potential?

WEBINAR 2003-03-18 By Zuoshang Xu, Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605 Zuoshang Xu led this live discussion on 18 March 2003. Readers are invited to submit additional comments by using our Co

CAA: We All Know It's There, But Just What Is It Doing in Alzheimer's?

WEBINAR 2003-03-12 Steven Greenberg and Mathias Jucker led this live discussion on 12 March 2003. Readers are invited to submit additional comments by using our Comments form at the bottom of the page. Transcript unavailable. Background Text By Steven Greenberg and Mathias

Probing PPARγ? Agonists: Could Diabetes Drugs Treat Alzheimer's Disease?

WEBINAR 2002-12-16 Elena Galea and Douglas Feinstein led this live discussion on 16 December 2002. Readers are invited to submit additional comments by using our Comments form at the bottom of the page.   See the Preamble (.pdf) to this discussion Look up abstracts of the S

Intraneuronal Aβ Accumulation—More Evidence, Less Controversy?

WEBINAR 2002-11-26 Gunnar Gouras led this live discussion on 26 November 2002. Readers are invited to submit additional comments by using our Comments form at the bottom of the page. Transcript: Live discussion held 26 November 2002 featuring Gunnar Gouras Participants: Gun