PAPER Wang C, Yang M, Liu D, Zheng C
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PAPER Gunawan C, Fleming C, Irga PJ, Jien Wong R, Amal R, Torpy FR, Mojtaba Golzan S, McGrath KC
Neurodegenerative effects of air pollutant Particles: Biological mechanisms implicated for Early-Onset Alzheimer's disease.
Environ Int. 2024 Mar;185:108512. Epub 2024 Feb 23 PubMed.Debomoy Lahiri, Bryan Maloney on Epigenetic Shenanigans—In AD, Chromatin Opens Up in Blood Immune Cells
COMMENT We read the this paper (Ramakrishnan et al., 2024) with great interest and agree with others’ comments already posted in Alzforum. We have long maintained that there is an important role for epigenetic markers in the etiology of AD (Maloney and Lahiri, 20
Chiara Cirelli on While a Fly Sleeps, Its Glia Burn Neuronal Lipids to Refresh the Brain
COMMENT This is a beautiful study with compelling results. That the authors discovered a role for glia in protecting neurons from wake-related oxidative stress is quite unexpected and eye-opening. The next step will be to test the extent to which this mechanism a
Erik Musiek on While a Fly Sleeps, Its Glia Burn Neuronal Lipids to Refresh the Brain
COMMENT This is an exciting finding. It builds on work from Hugo Bellen’s lab, which showed that astrocytes can take up lipid droplets from stressed/injured neurons as a neuroprotective mechanism. This new paper provides a novel connection to sleep deprivation, w
Sarah Cohen on While a Fly Sleeps, Its Glia Burn Neuronal Lipids to Refresh the Brain
COMMENT This exciting new paper from the Seghal lab makes an unexpected connection between reactive oxygen species (ROS), lipid metabolism, and sleep. Previous work had shown that neurons release ROS-damaged peroxidated lipids when overexcited or stressed; these
Russell Swerdlow on While a Fly Sleeps, Its Glia Burn Neuronal Lipids to Refresh the Brain
COMMENT This is a fantastic study. It addresses fundamental issues of brain bioenergetic metabolism that relate and link to several AD-relevant phenomena, including neuron-glia interplay, apolipoprotein E biology, lipid metabolism, oxidative stress, circadian rhy
Emanuele Buratti on ‛iNET’ Cultures Expose NPTX2 as TDP-43 Henchman
COMMENT One great drawback when studying proteins like TDP-43 is the incredible number of genes whose expression is controlled by this protein, and which become misregulated following TDP-43 aggregation in pathological conditions. From a therapeutic point of view
Carlos Cruchaga on Proteomics Uncovers Potential Markers of Early Autosomal Dominant AD
COMMENT Adapted from a LinkedIn post. In order to fully understand the biology of Alzheimer’s disease, to create new predictive models, and to identify novel causal and druggable targets, we need large-scale, unbiased omic analyses. For the last three years, my l
Mariagnese Barbera, Jaakko Tuomilehto, Miia Kivipelto on In Diabetes, Tight Blood Sugar Control Staves Off Dementia
COMMENT Wang and colleagues' interesting study showed that a multidisciplinary diabetes management program in primary care settings was associated with a reduced risk of dementia incidence among patients with T2D in a cohort study in Hong Kong. Patients with
Ashutosh Kumar on Not So Fast—The Brain Has Three Meningeal Membranes After All
COMMENT A team of human anatomists, clinicians, and basic scientists have come together to systematically examine the controversy of intermediate leptomeningeal layer or SLYM in the brain. A preprint of the document is at this open-access link: https://osf.io/5mh
Ashutosh Kumar on And Then There Were Four: A New Meningeal Membrane Discovered
COMMENT A team of human anatomists, clinicians, and basic scientists have endeavored to examine the controversy over existence of SLYM, see open access document here https://osf.io/5mhtu/?view_only=e5a2bf6004dd498db87587ec8c32df9e drashutoshkumar_380926 0
Mary Newport on Iatrogenic Alzheimer's disease in recipients of cadaveric pituitary-derived growth hormone.
COMMENT Might we consider that, if prions can induce Aβ seeding, microbes such as herpes simplex virus (HSV) and herpes varicella-zoster, which are transmissible, might as well? For example, studies have shown that HSV, other viruses, and many other types of orga
Susan Davis on Prospective 25-year surveillance of prion diseases in France, 1992 to 2016: a slow waning of epidemics and an increase in observed sporadic forms.
COMMENT Could sCJD be due to as-yet-unidentified transmission routes? Has transmission via eye procedures been excluded? 0 sumada_347611 Prion Seeds Distribute throughout the Eyes of Sporadic Creutzfeldt-Jakob Disease Patients.
Tengfei Guo on Microglial Reactivity Correlates with Presynaptic Loss Independent of β-Amyloid and Tau.
COMMENT In this study, we found that higher baseline levels of CSF microglial biomarkers were related to faster rates of CSF sTREM2 increase and CSF PGRN decrease. Elevated CSF p-Tau181 was associated with higher levels of CSF microglial biomarkers and faster rat
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