• X E14X
    1. E14X
  • X S16F
    1. S16F
  • X G17E
    1. G17E
  • X V27M
    1. V27M
  • X A28V
    1. A28V
  • X S31F
    1. S31F
  • X D39E D39G
    1. D39E
    2. D39G
  • X H43Y
    1. H43Y
  • X G45E
    1. G45E
  • X G58A
    1. G58A
  • X R52C R52H
    1. R52C
    2. R52H
  • X Q33Ter
    1. Q33Ter
  • X Y38C
    1. Y38C
  • X W44Ter
    1. W44Ter
  • X R47H R47C
    1. R47H
    2. R47C
  • X W50C
    1. W50C
  • X R62H R62C
    1. R62H
    2. R62C
  • X N68K
    1. N68K
  • X L72V
    1. L72V
  • X R98W
    1. R98W
  • X T66M
    1. T66M
  • X W78X
    1. W78X
  • X D86V
    1. D86V
  • X D87N
    1. D87N
  • X G90Vfs
    1. G90VfsX99
  • X T96K
    1. T96K
  • X A105RFS A105T A105V
    1. A105Rfs
    2. A105T
    3. A105V
  • X S116C
    1. S116C
  • X A130S
    1. A130S
  • X D131D
    1. D131D
  • X L133L
    1. L133L
  • X R136Q R136W
    1. R136Q
    2. R136W
  • X E151K
    1. E151K
  • X S162R
    1. S162R
  • X A192T
    1. A192T
  • X A196T
    1. A196T
  • X H215Q
    1. H215Q
  • X T223I
    1. T223I
  • X V126G
    1. V126G
  • X D134G
    1. D134G
  • X H157Y
    1. H157Y
  • X K186N
    1. K186N
  • X W198Ter
    1. W198Ter
  • X L211P
    1. L211P
  • X G145W
    1. G145W
  • X

    TREM2 is cleaved by ADAM protease on the cell surface to release soluble TREM2 (sTREM2). The remaining C‐terminal fragment (CTF) is subsequently cleaved by γ‐secretase in the membrane.

    NEWS: TREM2 Cleavage Site Pinpointed: A Gateway to New Therapies?