The Role of ApoE in Alzheimer's Disease: An Alternative View

11 Dec 2001

Keith Crutcher led this live discussion on 11 December 2001. Readers are invited to submit additional comments by using our Comments form at the bottom of the page. Transcript: Live discussion held on 11 December 2001. Participants: Keith Crutcher, Nico S

Gonadal Hormone Withdrawal, Apoptosis, and Generation of Beta Amyloid Peptide: A Vicious Cycle of Amyloidogenesis and Neurotoxicity in Alzheimer's Disease

• 5 Comments

05 Dec 2001

Sam Gandy led this live discussion on 5 December 2001. Readers are invited to submit additional comments by using our Comments form at the bottom of the page. Transcript: Live discussion held 5 December 2001, noon-1 p.m. (EST). Participants: Dick Lloyd, S

Calcium Signaling Deficit in the Origin of Alzheimer's Disease

• 8 Comments

07 Sep 2001

Live discussion and panel of participants scheduled for 7 September 2001.     Summary: "Ca2+ deficit" hypothesis Summary: "Natural origin" hypothesis for plaques and tangles The live chat and panel of participants scheduled for 7 Septe

Nomenclature Discussion

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15 Aug 2001

George Perry and Mark A. Smith led this live discussion on 14 August 2001. Readers are invited to submit additional comments by using our Comments form at the bottom of the page. Transcript: Live discussion held 14 August 2001, 5 p.m. EST Participants: Co

New Theories of Presenilin Function

12 Dec 2000

Chris Weihl led this live discussion on 12 December 2000. Readers are invited to submit additional comments by using our Comments form at the bottom of the page. Transcript: Live discussion held on 12 December 2000 and moderated by Chris Weihl. Participan

Generation of an Apoptotic Intracellular Peptide by γ-secretase Cleavage of Alzheimer's β-amyloid Precursor Protein

20 Sep 2000

Benjamin Wolozin, with Luciano D'Adamio and Eddie Koo, led this live discussion on 20 September 2000. Readers are invited to submit additional comments by using our Comments form at the bottom of the page.   Journal of Alzheimer's Disease. 2000;

Intracellular Aβ in Alzheimer's Disease

• 3 Comments

16 May 2000

Gunnar Gouras led this live discussion on 16 May 2000. Readers are invited to submit additional comments by using our Comments form at the bottom of the page. Transcript: Live discussion held 16 May 2000.   Participants: Bruce Yankner, Huaxi Xu, Austin Ya

Protofibrillar Aβ in Alzheimer's Disease

17 Feb 2000

Dennis Selkoe, Dean Hartley, and William Klein led this live discussion on 17 February 2000. Readers are invited to submit additional comments by using our Comments form at the bottom of the page. Transcript: Live discussion held Thursday, 17 February 200

Beta-Catenin and PS1

13 Aug 1999

Chris Weihl, with Bruce Yankner, Benjamin Wolozin, Eddie Koo, and Kenneth Kosik led this live discussion on 13 August 1999. Readers are invited to submit additional comments by using our Comments form at the bottom of the page. Transcript: Live discussion

Pin1, Tau and the Cell Cycle in Alzheimer Disease

03 Aug 1999

June Kinoshita, with Peter Davies, led this live discussion on 3 August 1999. Readers are invited to submit additional comments by using our Comments form at the bottom of the page.   Paper under discussion: Lu, Pei-Jung, Wulf, Gerburg, Zhou, Xiao Zhen, D

In Search of γ-Secretase

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05 May 1999

Peter Nelson, with Dennis Selkoe, John Hardy, and Alain Israel, led this live discussion on 5 May 1999. Readers are invited to submit additional comments by using our Comments form at the bottom of the page. Transcript: Live discussion with Dennis Selkoe,

Apoptosis in Alzheimer Disease

24 Mar 1999

Paul Coleman, with Carl Cotman, Mark A. Smith, and George Perry, led this live discussion on 24 March 1999. Readers are invited to submit additional comments by using our Comments form at the bottom of the page. Transcript: Live discussion held 24 March 1

Frameshift Mutants of β Amyloid Precursor Protein and Ubiquitin-B in Alzheimer's and Down's Syndrome Patients

28 May 1998

Chris Weihl led this live discussion on 28 May 1999. Readers are invited to submit additional comments by using our Comments form at the bottom of the page.   Article under discussion van Leeuwen FW, de Kleijn DPV, van den Hurk HH, Neubauer A, Sonnemans M

Alzheimer Presenilins in the Nuclear Membrane, Interphase Kinetochores, and Centrosomes Suggest a Role in Chromosome Segregation

20 Mar 1998

Marc Paradis led this live discussion on 20 March 1998. Readers are invited to submit additional comments by using our Comments form at the bottom of the page. Paper under Discussion: Li JH, Xu M, Zhou H. Ma J. and Potter H. Alzheimer presenilins in the n

Isolation of Single Immunohistochemically Identified Whole Neuronal Cell Bodies from Post-Mortem Human Brain for Simultaneous Anlaysis of Multiple Gene Expression

27 Feb 1998

Peter T. Nelson led this live discussion on 27 February 1998. Readers are invited to submit additional comments by using our Comments form at the bottom of the page. Paper Under Discussion: Cheetham JE, Coleman PD, Chow N. Isolation of Single Immunohistoc