Mouse Tau Knock-Ins: A Tale of Two Pathologies
Some knock-ins phosphorylate tau, others seed its aggregation.
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Next Up—Combination Trials for Sporadic Alzheimer’s
A platform trial to test multiple therapies targeting tau and amyloid may finally start. Separately, Eisai is already testing anti-amyloid and anti-tau therapies concurrently.
Tau Global Conference Promises Primary Tauopathy Trials
New trials for corticobasal syndrome and progressive supranuclear palsy slated to begin this year.
Tau Global Conference
Tau Global Conference Promises Primary Tauopathy Trials Next Up—Combination Trials for Sporadic Alzheimer’s Mouse Tau Knock-Ins: A Tale of Two Pathologies Modeling Tauopathies With Human Tissue About 600 scientists gathered in central London for the Tau G
A First: FDA Approves Alzheimer’s Blood Test
Fujirebio’s Lumipulse G p-tau217/Aβ42 immunoassay detects plaques as accurately as does the company’s previously cleared cerebrospinal fluid test.
Human Cortex Layers Up Sooner Than You Think
Spatial transcriptomics unveiled the organization of all six cortical layers three months before they come into view under the microscope.
Nearly Half of Cognitively Healthy People Choose Not to Learn Amyloid Status
In a longitudinal aging study, 40 percent of participants declined disclosure of biomarker results, citing the burden of knowing and lack of treatments for preclinical AD.
In Clinical Use, Most ARIA Occurs in People With Dementia, Not MCI
Of the first 234 people on Leqembi at Washington University, those with mild dementia had 2.5 times the risk of edema, 15 times the risk of ARIA symptoms, as those with MCI.
Heavy Tau Snuffs Out Hippocampal Bursts
High–molecular–weight tau stifles the rapid firing of neurons in the hippocampus. Could this explain the earliest signs of memory trouble in Alzheimer’s?
Alzheimer’s Variants Leave Astrocytes CLUless
Clusterin calms inflammatory astrocyte signaling, quelling microglia reactivity. Carriers of common risk variants miss out on the benefit.
Listen Up: One in Three Dementia Cases Due to Hearing Loss
According to a new study, 32 percent of new dementia diagnoses can be attributed to mid-life hearing loss.
Troubling Trend? Cytotoxic T cells Swarm Midbrain in PSP
The sighting in progressive supranuclear palsy, a 4R-tauopathy, adds to a growing list of neurodegenerative diseases where the invading lymphocytes are implicated.
SUMO Chains Restrain TDP-43, Prevent Aggregation
Three studies uncover a stress-activated tag keeping the protein soluble.
Confirmed: Lowering Blood Pressure Cuts Risk of Dementia
Among 34,000 Chinese villagers, better control of hypertension dropped the risk of all-cause dementia and mild cognitive impairment by 16 percent over four years.
Next Act for Amyloid Immunotherapy: Be Safer, Target Tau, Too
Eisai tests concurrent Aβ and tau immunotherapy in sporadic AD. Under-the-skin 'remy' avoids donanemab's immunogenicity.
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