ALZGENE

AlzGene is a collection of published Alzheimer's disease genetic association studies, with random-effects meta-analyses for polymorphisms with genotype data in at least three case-control samples. This database was last updated in 2011, and  no further changes to the database are anticipated.

HEX (HEALTHY EXOMES)

The Healthy Exomes database is a repository of genetic variants predicted to be benign with respect to age-associated neurodegenerative brain disease. It contains whole-exome sequencing results from nearly 500 individuals over the age of 60 who did not have a neurodegenerative disease diagnosis or disease-associated neuropathology at the time of their death. This database provides a unique reference cohort of aged individuals without evidence of neurodegenerative disease. The HEX database is developed in collaboration with Jose Bras and Rita Guerreiro, University College London.

MUTATIONS

This database is a repository of variants in genes implicated in Alzheimer’s disease. Currently, it includes the three genes associated with autosomal-dominant AD (APP, PSEN1, PSEN2) plus three genes associated with AD through association studies or pathology (APOE, MAPT, and TREM2). The goal is to provide a comprehensive list of variants in these genes that have been reported in the literature, and to briefly describe associated clinical and neuropathological features as well as functional effects.