More Clues in the Case, but γ-Secretase Remains at Large
In the search for the elusive γ-secretase that cleaves β-amyloid precursor protein (APP), much attention has been paid to the protein Notch, which is critical in developmental pathways...
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Watching Enzymes at Work
Three-dimensional images of enzymes at work in cells? This is the promise of a new advance in microscopy called fluorescence lifetime imaging microscopy (FLIM)...
Making Dirty RNA from Clean DNA
Fred Van Leeuwen and his colleagues reported last year (Science 9 Jan 1998;279:242-7) that some neurons in Alzheimer's patients contain mutant RNA coding for APP and ubiquitin...
More Details to the β-catenin Picture
β-catenin, a protein that regulates transcription, has drawn attention in Alzheimer's research because it interacts with PS1 and PS2. It was also recently found that AD patients with the PS1 mutation have markedly reduced β-catenin...
Abnormal Motion Processing in AD
It has long been assumed that the reason Alzheimer's patients tend to get lost is because of memory failure and confusion. But a new study appearing in tomorow’s issue of Neurology suggests that impaired processing of visual information...
Prion Soup
Researchers in the U.K. have created conditions inside a test tube in which human prion protein can flip back and forth between normal forms and abnormal forms associated with neurodegenerative disease...
Human ApoE Slows Plaque Deposition in Tg Mice
Ever since the ApoE4 allele was identified as a risk factor in late-onset Alzheimer's, researchers have speculated that ApoE interacts with β-amyloid. Several years ago, Kelly Bales and colleagues at Lilly Research Laboratories...
June Kinoshita Interviews John Hardy
June Kinoshita Interviews John Hardy
Major Early Intervention Study Launched
The UCSD Alzheimer's Disease Cooperative Study Center is launching a $22 million study to determine whether medical intervention in individuals with mild cognitive impairment (MCI)...
Chlamydia-Heart Disease Link Found
In the mid-1980s, Finnish researchers reported that 68 percent of heart attack patients and 50 percent of those with coronary heart disease had antibodies to the bacterium <em>Chlamydia pneumoniae</em>, as compared to 17 percent of healthy controls...
Computer Simulation Captures Protein Misfolding
Scientists at Sandia National Laboratories and M.I.T. have created the first computer simulation that successfully models how protein misfolding can occur...
Insight Into Neuronal Asymmetry
Neurons are highly polarized cells, with certain proteins within them clearly restricted to specific regions of the plasma membrane. Yet they lack any obvious barriers to free protein diffusion...
LTP Deficits Seen in Hsiao Mice
Several years ago, Karen Hsiao and colleagues at the University of Minnesota reported that mice containing an FAD mutant form of the human amyloid precursor protein (APP) are impaired in their ability to learn...
ApoE4 Affects Recovery from Head Injury
The E4 gene variant of apolipoprotein E (ApoE) confers an increased risk of developing AD, but the mechanisms by which it does so are not understood. ApoE plays a role...
Keith A. Crutcher Interviews Rachael Neve
Keith A. Crutcher Interviews Rachael Neve
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