Semaglutide Does Not Treat Alzheimer’s. Could it Prevent Dementia?
Topline results presented at CTAD revealed that semaglutide definitively failed to benefit people with early symptomatic AD.
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Hello New Type of Aβ42 Fibril Discovered in 83-Year-Old Man
Aβ42 Type III, found postmortem in soluble fraction of brain extract, comprises three protofilaments.
TDP-43 Conference Marks Concerted Effort to Finally Snag Biomarkers
Steps Forward: Immunoassays for cryptic HDGFL2 flag TDP-43 proteinopathy in diverse disorders. Companies have moved a PET ligand into Phase 1 trials.
GNPC: Mining 40,000 Fluid Samples for Neurodegeneration Markers
Assembled by the Global Neurodegeneration Proteomics Consortium, the dataset represents the largest disease-specific proteomics discovery effort yet.
NULISA Proteomics Platform Takes Off for Diagnostics, Discovery
The multiplex panel is highly sensitive, easy to use, and can interrogate blood for 123 proteins linked to neurodegenerative disease.
Introducing CagA, a Bacterial Amyloid Buster
Made by Helicobacter pylori, the protein impedes fibrillization of both functional and pathogenic amyloid.
Blood Tests Forecast Dementia in Down’s Syndrome
Rising plasma p-tau217 precedes cognitive decline in Trisomy 21. GFAP flags future amyloid buildup.
Regular Running Wards Off Alzheimer’s Signatures in the Hippocampus
In mice, exercise spurred gene-expression changes in neurons, microglia, astrocytes, and other cells, reversing many of the detrimental signatures induced by amyloidosis.
A Back Door to the Brain for Myeloid Cells?
Bone-marrow–derived immune cells infiltrate the mouse brain via a meningeal fold, researchers report.
Do Strong Immune Responses Protect People from Dementia?
People with high antibody titers to common viruses were less likely to have Alzheimer’s pathology or dementia. The immunoglobulin IGDCC4 might protect.
T Cells from the Gut Occupy a Niche in Human and Mouse Brain
Residing in the fornix just beneath the hippocampus, the immune cells regulate feeding behavior.
The Cold Shoulder: Grant Freezes, Indefinite Delays Take Their Toll
Beyond outright grant terminations, NIH funding cuts have also manifested as mysterious suspensions and lengthy delays.
Terminated, Delayed—AD Scientists Weather Storm of Uncertainty
NIH funding cuts have taken a toll on Alzheimer’s research in the form of grant terminations, funding suspensions, and yawning holdups. DEI was hit hardest.
Sniffing Out Early Signs of Parkinson’s Disease
A simple seven-scent smell test may effectively identify people with Parkinson’s disease or dementia with Lewy bodies.
No Bull—Taurine Not a Marker of Aging, After All
A new study finds that a person’s plasma levels of the non-essential amino acid do not change with age.
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