AlzBiomarker
Multiple System Atrophy vs Alzheimer's Disease: NFL (CSF)
In our meta-analysis of three studies, the levels of neurofilament light chain in the cerebrospinal fluid of people with multiple system atrophy were approximately double those of people with Alzheimer's disease (effect size = 1.801, p = 0.0004). Meta-analyses comparing MSA patients to control subjects found increases on the order of four-fold in the patients (Bridel et al., 2019; Cong et al., 2020; Wang et al., 2019).
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