Alzpedia
BACE1
Synonyms: beta-secretase 1, beta-Site amyloid beta A4 precursor protein-cleaving enzyme, memapsin-2 (membrane-associated aspartic protease 2), aspartyl protease 2 (ASP2), HSPC104
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News
- BACE—Substrates, Functions, Developmental Phenotypes
- Meeting Explores Complex Biology of BACE Regulation
- Paper Alert: BACE1 Required for Muscle Spindle, Motor Control
- Lilly Halts Phase 2 Trial of BACE Inhibitor Due to Liver Toxicity
- Paracrine Signal From BACE1-Clipped Neuregulin Rescues Myelin
- BACE Inhibitors Barrel Forward—Next Hurdles: Safety, Efficacy
- Rounding Second BACE: Another Route to Memory Loss?
- Wave of New BACE Inhibitors Heading to Phase 2
- BACE Secrets: Newly Identified Substrates May Regulate Plasticity
- Not the Usual Suspects: Tracking BACE Inhibition, Axon Role
- Q&A With Merck’s Johan Luthman
- Smuggling Antibodies to BACE Across the Blood-Brain Barrier
- Barcelona: Out of Left Field—Hit to The Eye Kills BACE Inhibitor
- Keystone: BACE, Age, Stress, Energy—Is Translation to Blame?
- BACE Regulates Sodium Channels, Neuronal Excitability
- Madrid: BACE News Roundup, Part 1
Papers
- Dislich B, Lichtenthaler SF. The Membrane-Bound Aspartyl Protease BACE1: Molecular and Functional Properties in Alzheimer's Disease and Beyond. Front Physiol. 2012;3:8. PubMed.
- Tan J, Evin G. β-Site APP-cleaving enzyme 1 trafficking and Alzheimer's disease pathogenesis. J Neurochem. 2012 Mar;120(6):869-80. PubMed.
- Kandalepas PC, Vassar R. Identification and biology of β-secretase. J Neurochem. 2012 Jan;120 Suppl 1:55-61. PubMed.
- Sun X, Bromley-Brits K, Song W. Regulation of β-site APP-cleaving enzyme 1 gene expression and its role in Alzheimer's disease. J Neurochem. 2012 Jan;120 Suppl 1:62-70. PubMed.
- Decourt B, Sabbagh MN. BACE1 as a potential biomarker for Alzheimer's disease. J Alzheimers Dis. 2011;24 Suppl 2:53-9. PubMed.
- Vassar R, Kovacs DM, Yan R, Wong PC. The beta-secretase enzyme BACE in health and Alzheimer's disease: regulation, cell biology, function, and therapeutic potential. J Neurosci. 2009 Oct 14;29(41):12787-94. PubMed.