Alzpedia
Presenilin-1 (PSEN1)
Synonyms: PS1, PS-1, S182, AD3
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Alzpedia Citations
Further Reading
News
- Going to Biomarker Extremes to Find Rare Alzheimer’s Variants
- Drug Company Halts Development of γ-Secretase Inhibitor Avagacestat
- Evidence Mounts That Some γ-Secretase Modulators Bind Presenilin
- Paris: Semagacestat Autopsy and Other News of Trial Tribulations
- First Crystal Structure of a Presenilin
- Presenilins and Calcium: A Lysosomal Stew With Acid Controversy
- Colombians Come to Fore in Alzheimer’s Research, Mass Media
- Evidence Piles Up for Presenilins’ Role in Autophagy
- Sole Perp—PS1 Alone Reconstitutes γ-Secretase Activity
- Research Brief: Presenilin Simplicity—Evidence for Autoproteolysis
- Notch Your Average Joe—Grounds for PS1 Neurogenesis Inhibition?
- Mouse of a Different Color: Presenilin Mutations Affect Melanin
- Familial Alzheimer's Presenilin Gene Perturbs Neurogenesis?
Papers
- De Strooper B, Iwatsubo T, Wolfe MS. Presenilins and γ-Secretase: Structure, Function, and Role in Alzheimer Disease. Cold Spring Harb Perspect Med. 2012 Jan;2(1):a006304. PubMed.
- Tomita T, Iwatsubo T. Structural biology of presenilins and signal peptide peptidases. J Biol Chem. 2013 May 24;288(21):14673-80. PubMed.
- Wolfe MS. Processive proteolysis by γ-secretase and the mechanism of Alzheimer's disease. Biol Chem. 2012 Sep;393(9):899-905. PubMed.
- St George-Hyslop P, Fraser PE. Assembly of the presenilin γ-/ε-secretase complex. J Neurochem. 2012 Jan;120 Suppl 1:84-8. PubMed.
- Wolfe MS. γ-Secretase inhibitors and modulators for Alzheimer's disease. J Neurochem. 2012 Jan;120 Suppl 1:89-98. PubMed.
- Ho A, Shen J. Presenilins in synaptic function and disease. Trends Mol Med. 2011 Nov;17(11):617-24. PubMed.
- Tanzi RE. The genetics of Alzheimer disease. Cold Spring Harb Perspect Med. 2012 Oct;2(10) PubMed.