Antibody

acetylated Tau /ac-tau

Tools

Back to the Top

Clonality: polyclonal
Host: Rabbit
Isotype: IgG2b
Source: Ab708
Li Gan, Gladstone Institute of Neurological Disease Assistant Professor of Neurology University of California, San Francisco
Reference:
Min SW, 2010
Reactivity:
Reacts in: Human, Rat

Immunogen/Epitope

immunogen = a synthetic tau peptide (amino acids 160–182 for 2N4R tau isoform) containing acetylated lysines at positions 163 and 174 and 180

Specificity

Ab708 specifically recognizes tau acetylated by p300 under cell-free conditions. In HEK293T cells transfected with tau, overexpression of p300 markedly elevated the levels of ac-tau detected with Ab708 while the increase in the levels of t-tau was modest, suggesting that Ab708 preferentially recognizes p300-induced ac-tau in cultured cells. Ab708 recognizes human tau acetylated at positions 163, 174, or 180 and possibly other acetylated lysines on tau, but not nonacetylated tau

Comments / Questions

No Available Comments

Make a comment or submit a question

To make a comment you must login or register.

References

Paper Citations

  1. Min SW, Cho SH, Zhou Y, Schroeder S, Haroutunian V, Seeley WW, Huang EJ, Shen Y, Masliah E, Mukherjee C, Meyers D, Cole PA, Ott M, Gan L. Acetylation of tau inhibits its degradation and contributes to tauopathy. Neuron. 2010 Sep 23;67(6):953-66. PubMed.

External Citations

  1. Li Gan

Further Reading

No Available Further Reading