Antibody

Anti-phospho TDP-43 (ser409/410) (1D3)

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Clonality: monoclonal
Host: Rat
Isotype: IgG2ak
Source: Millipore
Catalog #: MABN14
Formulation: Purified in buffer containing 0.1 M Tris glycine with 0.05% sodium azide
Reactivity:
Reacts in: Human
Availability: Confirmed Oct 2014

Immunogen/Epitope

Ovalbumin-conjugated linear peptide corresponding to human TDP-43 phosphorylated at serine 409 and 410.

Specificity

This antibody recognizes human TDP-43 phosphorylated at serine 409 and 410.

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References

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Further Reading

Papers

  1. Mori K, Weng SM, Arzberger T, May S, Rentzsch K, Kremmer E, Schmid B, Kretzschmar HA, Cruts M, Van Broeckhoven C, Haass C, Edbauer D. The C9orf72 GGGGCC repeat is translated into aggregating dipeptide-repeat proteins in FTLD/ALS. Science. 2013 Mar 15;339(6125):1335-8. Epub 2013 Feb 7 PubMed.
  2. Dormann D, Capell A, Carlson AM, Shankaran SS, Rodde R, Neumann M, Kremmer E, Matsuwaki T, Yamanouchi K, Nishihara M, Haass C. Proteolytic processing of TAR DNA binding protein-43 by caspases produces C-terminal fragments with disease defining properties independent of progranulin. J Neurochem. 2009 Aug;110(3):1082-94. Epub 2009 Jun 9 PubMed.