Antibody

Tau (AT270)

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Clonality: monoclonal
Host: Mouse
Isotype: IgG1κ
Source: Pierce Thermo Scientific
Cat# MN-1050
References:
van Eersel, 2010
Julien, 2008
Luo, 2007
Shahani, 2006
Formulation: supernatant, affinity purified, no carrier or preservative<br />Also available biotin conj., MN-1050B
Reactivity:
Reacts in: Human

Immunogen/Epitope

immunogen == partially purified human PHF tau, aa. around phosphorylated Thr181

Specificity

PHF tau, tamgles and neurofilaments; no cross with recomb. unphospho tau; weak cross with normal tau

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References

Paper Citations

  1. van Eersel J, Ke YD, Liu X, Delerue F, Kril JJ, Götz J, Ittner LM. Sodium selenate mitigates tau pathology, neurodegeneration, and functional deficits in Alzheimer's disease models. Proc Natl Acad Sci U S A. 2010 Aug 3;107(31):13888-93. PubMed.
  2. Julien C, Tremblay C, Phivilay A, Berthiaume L, Emond V, Julien P, Calon F. High-fat diet aggravates amyloid-beta and tau pathologies in the 3xTg-AD mouse model. Neurobiol Aging. 2010 Sep;31(9):1516-31. Epub 2008 Oct 15 PubMed.
  3. Luo W, Dou F, Rodina A, Chip S, Kim J, Zhao Q, Moulick K, Aguirre J, Wu N, Greengard P, Chiosis G. Roles of heat-shock protein 90 in maintaining and facilitating the neurodegenerative phenotype in tauopathies. Proc Natl Acad Sci U S A. 2007 May 29;104(22):9511-6. PubMed.
  4. Shahani N, Subramaniam S, Wolf T, Tackenberg C, Brandt R. Tau aggregation and progressive neuronal degeneration in the absence of changes in spine density and morphology after targeted expression of Alzheimer's disease-relevant tau constructs in organotypic hippocampal slices. J Neurosci. 2006 May 31;26(22):6103-14. PubMed.

Further Reading

No Available Further Reading