Antibody

Tau phos Thr181 (AT270)

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Clonality: monoclonal
Host: Mouse
Isotype: IgG1κ
Source: Innogenetics
cat# BR-008
References:
Siderowf, 2010
Roberson, 2007
Götz, 2001
Oddo, 2005
Boekhoorn, 2006
distributed by Autogen Bioclear as 90207
Formulation: liquid, sterile filtered, PBS, no preservative, affinity purified
Reactivity:
Reacts in: Human

Immunogen/Epitope

immunogen = human tau40, aa. around phospho. Thr 181

Specificity

specific for tau phospho at Thr 181; as PHF-tau, tangles and neurofilaments; weak cross with normal tau;

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References

Paper Citations

  1. Siderowf A, Xie SX, Hurtig H, Weintraub D, Duda J, Chen-Plotkin A, Shaw LM, Van Deerlin V, Trojanowski JQ, Clark C. CSF amyloid {beta} 1-42 predicts cognitive decline in Parkinson disease. Neurology. 2010 Sep 21;75(12):1055-61. PubMed.
  2. Roberson ED, Scearce-Levie K, Palop JJ, Yan F, Cheng IH, Wu T, Gerstein H, Yu GQ, Mucke L. Reducing endogenous tau ameliorates amyloid beta-induced deficits in an Alzheimer's disease mouse model. Science. 2007 May 4;316(5825):750-4. PubMed.
  3. Götz J, Chen F, van Dorpe J, Nitsch RM. Formation of neurofibrillary tangles in P301l tau transgenic mice induced by Abeta 42 fibrils. Science. 2001 Aug 24;293(5534):1491-5. PubMed.
  4. Oddo S, Caccamo A, Green KN, Liang K, Tran L, Chen Y, Leslie FM, Laferla FM. Chronic nicotine administration exacerbates tau pathology in a transgenic model of Alzheimer's disease. Proc Natl Acad Sci U S A. 2005 Feb 22;102(8):3046-51. PubMed.
  5. Boekhoorn K, Terwel D, Biemans B, Borghgraef P, Wiegert O, Ramakers GJ, de Vos K, Krugers H, Tomiyama T, Mori H, Joels M, Van Leuven F, Lucassen PJ. Improved long-term potentiation and memory in young tau-P301L transgenic mice before onset of hyperphosphorylation and tauopathy. J Neurosci. 2006 Mar 29;26(13):3514-23. PubMed.

Further Reading

No Available Further Reading