Antibody

α-Tubulin (DM1A)

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Clonality: monoclonal
Host: Mouse
Isotype: IgG1
Source: Sigma Aldrich
Cat# T6199
References:
( Decker, 2010
Tackenberg, 2009
Nicholson, 2009
unspecified formulation)
Tanemura, 2006
Formulation: liquid, purified IgG, PBS, BSA, azide<br />Also available as ascites and as FITC conj.
Reactivity:
Reacts in: Bovine, Chicken, Human, Mouse

Immunogen/Epitope

immunogen = purified chick brain tubulin (epitope at aa 426-430)

Specificity

recognizes an epitope located at the C-terminal end of alpha-tubulin

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References

Paper Citations

  1. Decker H, Lo KY, Unger SM, Ferreira ST, Silverman MA. Amyloid-beta peptide oligomers disrupt axonal transport through an NMDA receptor-dependent mechanism that is mediated by glycogen synthase kinase 3beta in primary cultured hippocampal neurons. J Neurosci. 2010 Jul 7;30(27):9166-71. PubMed.
  2. Tackenberg C, Brandt R. Divergent pathways mediate spine alterations and cell death induced by amyloid-beta, wild-type tau, and R406W tau. J Neurosci. 2009 Nov 18;29(46):14439-50. PubMed.
  3. Nicholson AM, Ferreira A. Increased membrane cholesterol might render mature hippocampal neurons more susceptible to beta-amyloid-induced calpain activation and tau toxicity. J Neurosci. 2009 Apr 8;29(14):4640-51. PubMed.
  4. Tanemura K, Chui DH, Fukuda T, Murayama M, Park JM, Akagi T, Tatebayashi Y, Miyasaka T, Kimura T, Hashikawa T, Nakano Y, Kudo T, Takeda M, Takashima A. Formation of tau inclusions in knock-in mice with familial Alzheimer disease (FAD) mutation of presenilin 1 (PS1). J Biol Chem. 2006 Feb 24;281(8):5037-41. PubMed.

Further Reading

No Available Further Reading