Antibody

β-Amyloid [1-17] (6E10)

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Clonality: monoclonal
Host: Mouse
Isotype: IgG1
Source: Sigma Aldrich
Cat# A1474
References:
Serneels, 2009
Jimenez, 2008
Vasilevko, 2007
Formulation: ascites, protein-G, PBS, thimerosal
Reactivity:
Reacts in: Human, Mouse
mouse at high concentrations

Immunogen/Epitope

immunogen = synthetic peptide corr. to aa 1-17 of β-amyloid, with Glu substituted at position 11, conjugated to KLH. Epitope at aa 1-12

Specificity

monoclonal recognizes aa 1-17 of human amyloid β peptide; also recognizes the precursor forms and abnormally processed isoforms

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References

Paper Citations

  1. Serneels L, Van Biervliet J, Craessaerts K, Dejaegere T, Horré K, Van Houtvin T, Esselmann H, Paul S, Schäfer MK, Berezovska O, Hyman BT, Sprangers B, Sciot R, Moons L, Jucker M, Yang Z, May PC, Karran E, Wiltfang J, D'Hooge R, De Strooper B. gamma-Secretase heterogeneity in the Aph1 subunit: relevance for Alzheimer's disease. Science. 2009 May 1;324(5927):639-42. Epub 2009 Mar 19 PubMed.
  2. Jimenez S, Baglietto-Vargas D, Caballero C, Moreno-Gonzalez I, Torres M, Sanchez-Varo R, Ruano D, Vizuete M, Gutierrez A, Vitorica J. Inflammatory response in the hippocampus of PS1M146L/APP751SL mouse model of Alzheimer's disease: age-dependent switch in the microglial phenotype from alternative to classic. J Neurosci. 2008 Nov 5;28(45):11650-61. PubMed.
  3. Vasilevko V, Xu F, Previti ML, Van Nostrand WE, Cribbs DH. Experimental investigation of antibody-mediated clearance mechanisms of amyloid-beta in CNS of Tg-SwDI transgenic mice. J Neurosci. 2007 Dec 5;27(49):13376-83. PubMed.

Further Reading