Paper on α-Secretase Regulation Retracted

Leonard Guarente and colleagues at MIT have retracted a paper they published July 2010 in Cell. First author Gizem Donmez and colleagues had claimed that the histone deacetylase SIRT1 boosted α-secretase processing of Aβ precursor protein, reducing production of Aβ. Alzforum reported on this work when it was presented at a Keystone meeting and when the paper appeared in print (see Feb 2010 conference news and Jul 2010 research news).

In the retraction, published last August, Donmez and colleagues revealed that several figures were inappropriately manipulated. They claim the errors do not negate the main conclusions of the paper and note that others have since reported that SIRT1 upregulates α-secretase (see Theendakara et al., 2013; Lee et al., 2014).—Tom Fagan

Comments

No Available Comments

Make a Comment

To make a comment you must login or register.

References

News Citations

  1. Copper Mountain: Knight Vision—SIRT1 Aids ADAM10, Slays Aβ
  2. Research Brief: SIRTs Keep Brain Minty Fresh

Paper Citations

  1. Theendakara V, Patent A, Peters Libeu CA, Philpot B, Flores S, Descamps O, Poksay KS, Zhang Q, Cailing G, Hart M, John V, Rao RV, Bredesen DE. Neuroprotective Sirtuin ratio reversed by ApoE4. Proc Natl Acad Sci U S A. 2013 Nov 5;110(45):18303-8. PubMed.
  2. Lee HR, Shin HK, Park SY, Kim HY, Lee WS, Rhim BY, Hong KW, Kim CD. Cilostazol suppresses β-amyloid production by activating a disintegrin and metalloproteinase 10 via the upregulation of SIRT1-coupled retinoic acid receptor-β. J Neurosci Res. 2014 Nov;92(11):1581-90. Epub 2014 Jun 5 PubMed.

External Citations

  1. retraction

Further Reading

No Available Further Reading

Primary Papers

  1. Retraction notice to: SIRT1 suppresses β-amyloid production by activating the α-secretase gene ADAM10. Cell. 2014 Aug 14;158(4):959. PubMed. Retracted Paper.
  2. Donmez G, Wang D, Cohen DE, Guarente L. SIRT1 suppresses beta-amyloid production by activating the alpha-secretase gene ADAM10. Cell. 2010 Jul 23;142(2):320-32. PubMed. RETRACTED

Annotate

To make an annotation you must Login or Register.