Clonality: polyclonal
Host: Rabbit
Source: APPNeo
(Dr. Dale Bredesen, Buck Institute for Age Research)
Paper,
Paper
Reference:
Banwait, 2008
Formulation: affinity purified, borate buffer
Reactivity:
Reacts in: Human, Mouse

Immunogen/Epitope

immunogen = the peptide ₆₅₇CIHHGVVEVD₆₆₄, which includes the nine amino acids immediately preceding the caspase cleavage site at position 664 in AβPP, coupled to KLH

Specificity

recognizes the neo-epitope generated by cleavage of AβPP at Asp664 in its intracellular, C-terminal domain; recognizes APP that was truncated at Asp664 but not intact APP

Comments / Questions

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References

Paper Citations

1. Banwait S, Galvan V, Zhang J, Gorostiza OF, Ataie M, Huang W, Crippen D, Koo EH, Bredesen DE. C-terminal cleavage of the amyloid-beta protein precursor at Asp664: a switch associated with Alzheimer's disease. J Alzheimers Dis. 2008 Feb;13(1):1-16. PubMed.

External Citations

1. Dr. Dale Bredesen
2. Paper
3. Paper

Further Reading

No Available Further Reading