Research Models
Tg-mAPP/RAGE
Synonyms: APP/RAGE
Species: Mouse
Genes: APP, RAGE (AGER)
Mutations: APP K670_M671delinsNL (Swedish), APP V717F (Indiana)
Modification: APP: Transgenic; RAGE (AGER): Transgenic
Disease Relevance: Alzheimer's Disease
Strain Name: N/A
Genetic Background: C57BL/6
Availability: Available through Shirley ShiDu Yan
Neuropathology
Significantly increased activation of microglia and astrocytes compared to mice expressing mutant APP alone.
Cognition/Behavior
Tg-mAPP/RAGE mice display abnormalities in spatial learning and memory at age three to four months of age, whereas deficits occur later in mice expressing mutant APP alone and are less severe.
Modification Details
Mice overexpressing wild-type RAGE driven by the PDGF-β promoter were crossed with mice expressing human APP carrying the Swedish and Indiana mutations driven by PDGF-β promoter (The Jackson Lab: Stock# 004661-now extinct).
Related Strains
Mice expressing a dominant-negative form of RAGE (Tg-mAPP/DN-RAGE) were generated in parallel.
Last Updated: 06 Mar 2018
COMMENTS / QUESTIONS
No Available Comments
Make a comment or submit a question
To make a comment you must login or register.