Mestre H, Verma N, Greene TD, Lin LA, Ladron-de-Guevara A, Sweeney AM, Liu G, Thomas VK, Galloway CA, de Mesy Bentley KL, Nedergaard M, Mehta RI. Periarteriolar spaces modulate cerebrospinal fluid transport into brain and demonstrate altered morphology in aging and Alzheimer's disease. Nat Commun. 2022 Jul 6;13(1):3897. PubMed.

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  1. This paper provides new tools for a better understanding of the periarteriolar compartment. One problem that has held back the study of leptomeninges has been the lack of specific markers for leptomeninges. High-resolution three-dimensional microscopy, combined with the discovery of the ERTR7 marker, has shown the ultrastructure of the leptomeningeal coating of the arteries.

    While it has been known that pia mater has fenestrations (Alcolado et al., 1988), the different patterns of perforated pia around arteries shown here are novel. They may yield information on the pattern of dilated perivascular spaces related to the failure of drainage of interstitial fluid and cerebral amyloid angiopathy.  

    It will be interesting to relate the findings in this study with the functions of pia mater as a regulatory interface between CSF and the cerebral parenchyma.

    References:

    Alcolado R, Weller RO, Parrish EP, Garrod D. The cranial arachnoid and pia mater in man: anatomical and ultrastructural observations. Neuropathol Appl Neurobiol. 1988 Jan-Feb;14(1):1-17. PubMed.

    View all comments by Roxana Carare

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