Sun Y, Rong X, Lu W, Peng Y, Li J, Xu S, Wang L, Wang X.
Translational study of Alzheimer's disease (AD) biomarkers from brain tissues in AβPP/PS1 mice and serum of AD patients.
J Alzheimers Dis. 2015;45(1):269-82.
PubMed.
The Sun et al. paper shows that serum cathepsin B levels are higher in Alzheimer's disease (AD) patients than normal controls and that higher serum cathepsin B levels are correlated with reduced cognitive ability in AD patients. These data corroborate similar findings by Sundelof et al. and provide added support for serum cathepsin B being a possible AD biomarker.
Moreover, the paper shows that hippocampal cathepsin B levels are elevated in the cortices and hippocampi of double transgenic APPSwe/PSEN1 AD mice relative to wild-type mice. These data correlate with the increased cathepsin B gene expression in transgenic 5XFAD AD mice found by Bouter et al. Thus, elevated cathepsin B levels have now also been shown to occur in several AD mouse models.
References:
Bouter Y, Kacprowski T, Weissmann R, Dietrich K, Borgers H, Brauß A, Sperling C, Wirths O, Albrecht M, Jensen LR, Kuss AW, Bayer TA.
Deciphering the molecular profile of plaques, memory decline and neuron loss in two mouse models for Alzheimer's disease by deep sequencing.
Front Aging Neurosci. 2014;6:75. Epub 2014 Apr 16
PubMed.
Sundelöf J, Sundström J, Hansson O, Eriksdotter-Jönhagen M, Giedraitis V, Larsson A, Degerman-Gunnarsson M, Ingelsson M, Minthon L, Blennow K, Kilander L, Basun H, Lannfelt L.
Higher cathepsin B levels in plasma in Alzheimer's disease compared to healthy controls.
J Alzheimers Dis. 2010;22(4):1223-30.
PubMed.
Comments
ALSP, Inc.
The Sun et al. paper shows that serum cathepsin B levels are higher in Alzheimer's disease (AD) patients than normal controls and that higher serum cathepsin B levels are correlated with reduced cognitive ability in AD patients. These data corroborate similar findings by Sundelof et al. and provide added support for serum cathepsin B being a possible AD biomarker.
Moreover, the paper shows that hippocampal cathepsin B levels are elevated in the cortices and hippocampi of double transgenic APPSwe/PSEN1 AD mice relative to wild-type mice. These data correlate with the increased cathepsin B gene expression in transgenic 5XFAD AD mice found by Bouter et al. Thus, elevated cathepsin B levels have now also been shown to occur in several AD mouse models.
References:
Bouter Y, Kacprowski T, Weissmann R, Dietrich K, Borgers H, Brauß A, Sperling C, Wirths O, Albrecht M, Jensen LR, Kuss AW, Bayer TA. Deciphering the molecular profile of plaques, memory decline and neuron loss in two mouse models for Alzheimer's disease by deep sequencing. Front Aging Neurosci. 2014;6:75. Epub 2014 Apr 16 PubMed.
Sundelöf J, Sundström J, Hansson O, Eriksdotter-Jönhagen M, Giedraitis V, Larsson A, Degerman-Gunnarsson M, Ingelsson M, Minthon L, Blennow K, Kilander L, Basun H, Lannfelt L. Higher cathepsin B levels in plasma in Alzheimer's disease compared to healthy controls. J Alzheimers Dis. 2010;22(4):1223-30. PubMed.
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