Research Models
TMHT (Thy-1 mutated human tau)
Synonyms: TAU 441, hTAU441, TAU441 V337M R406W
Species: Mouse
Genes: MAPT
Mutations: MAPT V337M, MAPT R406W
Modification: MAPT: Transgenic
Disease Relevance: Alzheimer's Disease
Strain Name: N/A
Genetic Background: C57Bl/6xDBA
Availability: The CRO Scantox Neuro offers research services with this line.
Neuropathology
Increased total tau and phosphorylated tau species (Thr181, Ser199, Thr231) in the amygdala and hippocampus starting at three months.
Cognition/Behavior
Spatial memory deficits starting at five months by the Morris water maze. Olfactory deficits at five months indicated by the buried food test. No motor deficits (by rotarod, beam walk) or depressive behavior as indicated by the forced swim test.
Modification Details
Transgene consists of human MAPT Tau441 (2N/4R) with mutations V337M and R406W under control of the Thy1 promoter.
Availability
The contract research organization Scantox Neuro offers research services with this line.
Phenotype Characterization
When visualized, these models will distributed over a 18 month timeline demarcated at the following intervals: 1mo, 3mo, 6mo, 9mo, 12mo, 15mo, 18mo+.
Absent
- Plaques
No Data
Plaques
Absent.
Tangles
Tangles at 4 months and progress with age.
Cognitive Impairment
Cognitive impairment by 5 months as measured by the Morris Water Maze.
Last Updated: 03 Apr 2024
References
External Citations
Further Reading
No Available Further Reading
COMMENTS / QUESTIONS
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