This NOVA special tracks the quest for an effective treatment for AD. Three-time Emmy award winning producer Sarah Holt explains the biology behind this devastating disease, from Alois Alzheimer’s 1906 description of amyloid plaques and neurofibrillary tangles, to the mutations that cause these pathological hallmarks, and the modern PET scans that detect them in the living brain. Featuring interviews throughout from leading researchers in the field, Holt’s film explores the staggering cost of turning research into successful therapeutics, all the while showing the human toll through the lens of affected people who chronicle their own decline. The movie is freely available here.

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