Saunders AM, Strittmatter WJ, Schmechel D, George-Hyslop PH, Pericak-Vance MA, Joo SH, Rosi BL, Gusella JF, Crapper-MacLachlan DR, Alberts MJ. Association of apolipoprotein E allele epsilon 4 with late-onset familial and sporadic Alzheimer's disease. Neurology. 1993 Aug;43(8):1467-72. PubMed.

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  1. Susceptibility Testing and Risk Assessment in Alzheimer Disease

Mutations

  1. APOE C130R (ApoE4)

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  1. ApoE4 major risk factor for late-onset AD; risk up threefold with one allele, 12-fold with two; ApoE2 protective