Choo IH, Ni R, Schöll M, Wall A, Almkvist O, Nordberg A. Combination of 18F-FDG PET and cerebrospinal fluid biomarkers as a better predictor of the progression to Alzheimer's disease in mild cognitive impairment patients. J Alzheimers Dis. 2013;33(4):929-39. PubMed.
AlzBiomarker Database
Meta-Analysis
- MCI-AD vs MCI-Stable : Aβ42 (CSF)
- MCI-AD vs MCI-Stable : tau-p181 (CSF)
- MCI-AD vs MCI-Stable : tau-total (CSF)
Curated Study Data
| Biomarker (Source) |
Cohort (N) |
Measurement Mean ± SD |
Method; Assay Name; Manufacturer |
Diagnostic Criteria |
|---|---|---|---|---|
| Aβ42 (CSF) |
MCI-AD (26) |
485 ± 93.5 pg/mL |
ELISA; INNO-BIA AlzBio3; Innogenetics |
Petersen et al., 1999; McKhann et al., 1984 |
| Aβ42 (CSF) |
MCI-Stable (51) |
639.1 ± 255.3 pg/mL |
ELISA; INNO-BIA AlzBio3; Innogenetics |
Petersen et al., 1999 |
| tau-p181 (CSF) |
MCI-AD (26) |
78.9 ± 26.1 pg/mL |
ELISA; INNO-BIA AlzBio3; Innogenetics |
Petersen et al., 1999; McKhann et al., 1984 |
| tau-p181 (CSF) |
MCI-Stable (51) |
76.6 ± 69.3 pg/mL |
ELISA; INNO-BIA AlzBio3; Innogenetics |
Petersen et al., 1999 |
| tau-total (CSF) |
MCI-AD (26) |
488.5 ± 154.6 pg/mL |
ELISA; INNO-BIA AlzBio3; Innogenetics |
Petersen et al., 1999; McKhann et al., 1984 |
| tau-total (CSF) |
MCI-Stable (51) |
313.3 ± 145 pg/mL |
ELISA; INNO-BIA AlzBio3; Innogenetics |
Petersen et al., 1999 |
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