Paper
- Milestone
- Alzforum Recommends
Kamal A, Almenar-Queralt A, LeBlanc JF, Roberts EA, Goldstein LS. Kinesin-mediated axonal transport of a membrane compartment containing beta-secretase and presenilin-1 requires APP. Nature. 2001 Dec 6;414(6864):643-8. PubMed.
Recommends
Please login to recommend the paper.
Comments
Roskamp Institute
This careful study rigorously tests a creative concept.
View all comments by Yong ShenWe have also detected BACE and APP, though not PS-1, in the same subcellular
compartment in AD neurons. That APP, BACE and PS1 are colocalized at the same
subcellular site in axons is intriguing and helpful to explain some important
issues, but the axonal membrane compartment may not be only major site for
Aβ generation (we found one or two sites in AD neurons). While sciatic
nerve is a simple, good model to test this working hypothesis, it is also
important to keep in mind that sciative nerve nerve cells differ from neurons
in the brain, especially cortical or hippocampal neurons. The authors use
corpus callosum as an axonal model, however, hippocampal or enthorinal cortex
neurons may also be worth pursuing. They all contain neuronal cell bodies
and their axonal projections and are pathologically affected areas in AD.
This is a very good paper.
Boston University School of Medicine
Despite intensive study the functions of APP are unknown, however an increasing
View all comments by Benjamin Wolozinnumber of experiments are identifying functions of APP. This paper is interesting
because it identifies a function that appears to be dependent on APP which,
if true, would be a major function of APP and further the understanding of
its basic biology.
Boston University School of Medicine
Despite intensive study the functions of APP are unknown, however an increasing number of experiments are identifying functions of APP. This paper is interesting because it identifies a function that appears to be dependent on APP which, if true, would be a major function of APP and further the understanding of its basic biology." - Benjamin Wolozin.
This paper provided us with a new function mechanism of APP, which may give us some clues as to how to decrease amyloid peptide while not disturbing the normal function.
Make a Comment
To make a comment you must login or register.