Schmid B, Hruscha A, Hogl S, Banzhaf-Strathmann J, Strecker K, van der Zee J, Teucke M, Eimer S, Hegermann J, Kittelmann M, Kremmer E, Cruts M, Solchenberger B, Hasenkamp L, van Bebber F, Van Broeckhoven C, Edbauer D, Lichtenthaler SF, Haass C. Loss of ALS-associated TDP-43 in zebrafish causes muscle degeneration, vascular dysfunction, and reduced motor neuron axon outgrowth. Proc Natl Acad Sci U S A. 2013 Mar 26;110(13):4986-91. PubMed.

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  1. A recent paper in Human Molecular Genetics also observed that TARDBPl compensates for the loss of TARDBP.

    References:

    Hewamadduma CA, Grierson AJ, Ma TP, Pan L, Moens CB, Ingham PW, Ramesh T, Shaw PJ. Tardbpl splicing rescues motor neuron and axonal development in a mutant tardbp zebrafish. Hum Mol Genet. 2013 Jun 15;22(12):2376-86. PubMed.

    View all comments by Tennore Ramesh

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  1. Paper Alert: Zebrafish Say TDP-43 Causes ALS by Loss of Function