Weidemann A, Eggert S, Reinhard FB, Vogel M, Paliga K, Baier G, Masters CL, Beyreuther K, Evin G. A novel epsilon-cleavage within the transmembrane domain of the Alzheimer amyloid precursor protein demonstrates homology with Notch processing. Biochemistry. 2002 Feb 26;41(8):2825-35. PubMed.

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  1. Several labs have all reported this cleavage event: , eg. Christian Haass and Yasuo Ihara. But what does this imply mean for g-secretase at 40 and 42? Are they recleaved or is this event co-incidental to ab generation?

    View all comments by Edward Koo

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