Lord A, Philipson O, Klingstedt T, Westermark G, Hammarström P, Nilsson KP, Nilsson LN. Observations in APP bitransgenic mice suggest that diffuse and compact plaques form via independent processes in Alzheimer's disease. Am J Pathol. 2011 May;178(5):2286-98. PubMed.
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The University of Queensland
That compact and diffuse plaques develop by independent mechanisms has been suggested in the first paper describing APPsw mutant APP23 mice: These mice develop almost exclusively compact plaques, whereas APP22 mice expressing APPsw together with V717I express mostly diffuse plaques (that do not mature to compact plaques).
References:
Sturchler-Pierrat C, Abramowski D, Duke M, Wiederhold KH, Mistl C, Rothacher S, Ledermann B, Bürki K, Frey P, Paganetti PA, Waridel C, Calhoun ME, Jucker M, Probst A, Staufenbiel M, Sommer B. Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology. Proc Natl Acad Sci U S A. 1997 Nov 25;94(24):13287-92. PubMed.
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