De Strooper B, Annaert W, Cupers P, Saftig P, Craessaerts K, Mumm JS, Schroeter EH, Schrijvers V, Wolfe MS, Ray WJ, Goate A, Kopan R. A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain. Nature. 1999 Apr 8;398(6727):518-22. PubMed.

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    • User Profile Image Hiroshi Mori
      Osaka City University Medical School
    • Posted:

    Unquestionably this is a core paper for AD study.

    View all comments by Hiroshi Mori

  2. The abstract states: 'Thus the targeting of gamma-secretase for the treatment of Alzheimer's disease may risk toxicity caused by reduced Notch signalling.' A potentially important cautionary note.

    View all comments by Paul Coleman

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  1. γ-secretase cleaves Notch