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Russo C, Schettini G, Saido TC, Hulette C, Lippa C, Lannfelt L, Ghetti B, Gambetti P, Tabaton M, Teller JK. Presenilin-1 mutations in Alzheimer's disease. Nature. 2000 Jun 1;405(6786):531-2. PubMed. Recommends Please login to recommend the paper. Comments Benjamin Wolozin Boston University School of Medicine Posted: 21 May 2002 Mutations in PS1 have been shown to increase production of Ab42. This current publication suggests that mutations in PS1 might also affect cleavage at the N-terminus of Ab, leading to production of truncated Ab. View all comments by Benjamin Wolozin Benjamin Wolozin Boston University School of Medicine Posted: 21 May 2002 This is a striking finding indicating that mutations in PS1 affect more than the C-terminus of Ab. View all comments by Benjamin Wolozin Make a Comment To make a comment you must login or register.
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Boston University School of Medicine
Mutations in PS1 have been shown to increase production of Ab42. This current publication suggests that mutations in PS1 might also affect cleavage at the N-terminus of Ab, leading to production of truncated Ab.
Boston University School of Medicine
This is a striking finding indicating that mutations in PS1 affect more than the C-terminus of Ab.
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