Almeida MC, Eger SJ, He C, Audouard M, Nikitina A, Glasauer SM, Han D, Mejía-Cupajita B, Acosta-Uribe J, Villalba-Moreno ND, Littau JL, Elcheikhali M, Rivera EK, Carrettiero DC, Villegas-Lanau CA, Sepulveda-Falla D, Lopera F, Kosik KS. Single-nucleus RNA sequencing demonstrates an autosomal dominant Alzheimer's disease profile and possible mechanisms of disease protection. Neuron. 2024 Jun 5;112(11):1778-1794.e7. Epub 2024 Feb 27 PubMed.

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Comments

  1. The increased level of LRP1 in astrocytes observed in this study is quite interesting. It could be a contributing mechanism of protection by the APOE Christchurch variant. Other mechanisms could include reduced binding to HSPG and other apoE receptors such as LRP1.

    While this type of study is informative, it’s overall suggestive and will need functional studies to clarify its relevance to the protective mechanism in disease models.

    View all comments by Guojun Bu

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This paper appears in the following:

News

  1. Different Cellular Mechanisms in Familial and Sporadic Alzheimer’s?

Mutations

  1. PSEN1 E280A (Paisa)
  2. APOE R154S (Christchurch)