Ryman DC, Acosta-Baena N, Aisen PS, Bird T, Danek A, Fox NC, Goate A, Frommelt P, Ghetti B, Langbaum JB, Lopera F, Martins R, Masters CL, Mayeux RP, McDade E, Moreno S, Reiman EM, Ringman JM, Salloway S, Schofield PR, Sperling R, Tariot PN, Xiong C, Morris JC, Bateman RJ, Dominantly Inherited Alzheimer Network. Symptom onset in autosomal dominant Alzheimer disease: a systematic review and meta-analysis. Neurology. 2014 Jul 15;83(3):253-60. Epub 2014 Jun 13 PubMed.

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Comments

  1. As the authors clearly articulate, these findings have clear implications for prediction of age at onset for clinical research. In addition, these results reiterate previous reports that autosomal dominant mutations have a broad range of onset, even well into the over-65-year range often associated with sporadic AD. Finally, this report strongly suggests that gene-gene and possibly gene-environment interactions that are shared within families have a significant influence on age at onset of autosomal dominant Alzheimer’s disease.

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