Goodman LD, Ralhan I, Li X, Lu S, Moulton MJ, Park YJ, Zhao P, Kanca O, Ghaderpour Taleghani ZS, Jacquemyn J, Shulman JM, Ando K, Sun K, Ioannou MS, Bellen HJ. Tau is required for glial lipid droplet formation and resistance to neuronal oxidative stress. Nat Neurosci. 2024 Oct;27(10):1918-1933. Epub 2024 Aug 26 PubMed.
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University of Pennsylvania
This is a very interesting finding describing a novel function for tau in the processing of peroxidated lipids from neurons. We previously showed that these lipids are transferred from neurons to glia in a daily sleep-dependent cycle, so this also indicates a role of tau in sleep function. Importantly, it suggests a mechanism for the link between sleep loss and neurodegeneration.
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