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Winkler DT, Biedermann L, Tolnay M, Allegrini PR, Staufenbiel M, Wiessner C, Jucker M. Thrombolysis induces cerebral hemorrhage in a mouse model of cerebral amyloid angiopathy. Ann Neurol. 2002 Jun;51(6):790-3. PubMed.
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Boston University School of Medicine
This is an interesting paper that describes a growing body of work with potentially significant clinical impact. Winkler and colleagues, who hail from the laboratory of Mathias Jucker, have investigated a transgenic APP mouse that exhibits a large amount of vascular amyloid. The vascular amyloid appears to contribute to a significant degree to the pathology in these mice. The consequences include hemorrhage and inflammation. The relationship between vascular amyloid and inflammation is a subject that has not been explored in AD research, which makes this model very interesting.
In the current manuscript, they have shown an intriguing relationship between vascular amyloid, hemorrhage and tPA treatment. This is important because there is a significant correlation between heart disease and AD, which increases the likelihood that AD patients will receive tPA. This work suggests a need for a clinical study to pursue the findings of this paper. If patients with vascular amyloidosis are at greater risk for hemorrhage, then tPA and possibly other anti-coagulant models might be contraindicated in patients with AD.
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