Yuan P, Condello C, Keene CD, Wang Y, Bird TD, Paul SM, Luo W, Colonna M, Baddeley D, Grutzendler J. TREM2 Haplodeficiency in Mice and Humans Impairs the Microglia Barrier Function Leading to Decreased Amyloid Compaction and Severe Axonal Dystrophy. Neuron. 2016 May 18;90(4):724-39. PubMed.

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News

  1. Barrier Function: TREM2 Helps Microglia to Compact Amyloid Plaques
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  3. New Mouse Models Reveal Unexpected Property of TREM2

Mutations

  1. TREM2 R47H

Research Models

  1. Trem2 KO (Colonna) x 5XFAD