Wolfe MS, Xia W, Ostaszewski BL, Diehl TS, Kimberly WT, Selkoe DJ. Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity. Nature. 1999 Apr 8;398(6727):513-7. PubMed.

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    • User Profile Image Hiroshi Mori
      Osaka City University Medical School
    • Posted:

    Unquestionably this is a core paper for AD study.

    View all comments by Hiroshi Mori

  2. A turning point in the molecular history of neurodegenerative disorders.

    View all comments by Andre Delacourte

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  1. Presenilin contains catalytic core of γ-secretase