Therapeutics
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| Name | Synonyms | FDA Status | Company | Target Type | Therapy Type | Approved For |
|---|---|---|---|---|---|---|
| AAB-003 | PF-05236812 | Alzheimer's Disease (Discontinued) | Janssen, Pfizer | Amyloid-Related | Immunotherapy (passive) | |
| Affitope AD02 | Alzheimer's Disease (Discontinued) | AFFiRiS AG | Amyloid-Related | Immunotherapy (active) | ||
| Alzhemed™ | Vivimind™, Tramiprosate, NC-531, homotaurine, 3-APS |
Alzheimer's Disease (Discontinued) | Neurochem, Inc. | Amyloid-Related | Supplement, Dietary | None |
| AN-1792 | AIP 001 | Alzheimer's Disease (Discontinued) | Janssen, Pfizer | Amyloid-Related | Immunotherapy (active) | None |
| Atabecestat | JNJ-54861911 , BACE inhibitor |
Alzheimer's Disease (Discontinued) | Janssen, Shionogi Pharma | Amyloid-Related | Small Molecule | |
| Avagacestat | BMS-708163 | Alzheimer's Disease (Discontinued) | Bristol-Myers Squibb | Amyloid-Related | Small Molecule | |
| Azeliragon | PF-04494700, TTP488 |
Alzheimer's Disease (Discontinued) | Pfizer, TransTech Pharma, Inc., vTv Therapeutics LLC | Amyloid-Related, Inflammation | Small Molecule | |
| Bapineuzumab | AAB-001 | Alzheimer's Disease (Discontinued) | Janssen, Pfizer | Amyloid-Related | Immunotherapy (passive) | |
| BI 1181181 | VTP 37948, BACE inhibitor |
Alzheimer's Disease (Discontinued) | Boehringer Ingelheim, Vitae Pharmaceuticals | Amyloid-Related | Small Molecule | |
| Clioquinol | iodochlorhydroxyquin, PBT-1 |
Alzheimer's Disease (Discontinued) | Prana Biotechnology Limited | Amyloid-Related, Metals | Small Molecule | |
| Crenezumab | MABT5102A , RG7412 |
Alzheimer's Disease (Discontinued) | AC Immune SA, Genentech, Hoffmann-La Roche | Amyloid-Related | Immunotherapy (passive) | None |
| DNL919 | TAK-920, ATV:TREM2 |
Alzheimer's Disease (Discontinued) | Denali Therapeutics Inc., Takeda Pharmaceutical Company | Amyloid-Related, Inflammation | Immunotherapy (passive) | |
| Elenbecestat | E2609, BACE inhibitor |
Alzheimer's Disease (Discontinued) | Biogen, Eisai Co., Ltd. | Amyloid-Related | Small Molecule | |
| EVP-0962 | EVP 0015962 | Alzheimer's Disease (Discontinued), Mild Cognitive Impairment (Discontinued) | FORUM Pharmaceuticals Inc. | Amyloid-Related | Small Molecule | |
| Flurizan™ | tarenflurbil , r-flurbiprofen, MPC-7869 |
Alzheimer's Disease (Discontinued) | Myriad Genetics & Laboratories | Amyloid-Related | Small Molecule | None |
| Gammagard® | Intravenous Immunoglobulin, IVIg |
Alzheimer's Disease (Discontinued) | Baxter Healthcare | Amyloid-Related, Inflammation | Immunotherapy (passive) | Immunodeficiency conditions |
| Gantenerumab | RO4909832, RG1450, R1450 |
Alzheimer's Disease (Discontinued) | Chugai Pharmaceutical Co., Ltd., Hoffmann-La Roche | Amyloid-Related | Immunotherapy (passive) | |
| Ibuprofen | Advil™, Nuprin™ , Motrin™ |
Alzheimer's Disease (Discontinued) | Amyloid-Related, Inflammation | Small Molecule | Pain and Fever | |
| Lanabecestat | AZD3293 , LY3314814, BACE inhibitor |
Alzheimer's Disease (Discontinued) | AstraZeneca, Eli Lilly & Co. | Amyloid-Related | Small Molecule | |
| Lu AF20513 | Alzheimer's Disease (Discontinued) | Lundbeck, Otsuka Pharmaceutical Co., Ltd. | Amyloid-Related | Immunotherapy (active) | ||
| LY2599666 | Alzheimer's Disease (Discontinued) | Eli Lilly & Co. | Amyloid-Related | Immunotherapy (passive) | ||
| LY2886721 | BACE inhibitor | Alzheimer's Disease (Discontinued), Mild Cognitive Impairment (Discontinued) | Eli Lilly & Co. | Amyloid-Related | Small Molecule | |
| LY3202626 | BACE Inhibitor | Alzheimer's Disease (Discontinued) | Eli Lilly & Co. | Amyloid-Related | Small Molecule | |
| PF-06648671 | Alzheimer's Disease (Discontinued) | Pfizer | Amyloid-Related | Small Molecule | ||
| PF-06751979 | BACE inhibitor | Alzheimer's Disease (Discontinued) | Pfizer | Amyloid-Related | Small Molecule | |
| Ponezumab | PF-04360365 | Alzheimer's Disease (Discontinued), Cerebral Amyloid Angiopathy (Discontinued) | Pfizer | Amyloid-Related | Immunotherapy (passive) | None |
| RG7129 | RO5508887, BACE Inhibitor |
Alzheimer's Disease (Discontinued) | Roche | Amyloid-Related | Small Molecule | |
| SAR228810 | Alzheimer's Disease (Discontinued) | Sanofi | Amyloid-Related | Immunotherapy (passive) | ||
| Semagacestat | LY450139 Dihydrate , hydroxylvaleryl monobenzocaprolactam |
Alzheimer's Disease (Discontinued) | Eli Lilly & Co. | Amyloid-Related | Small Molecule | None |
| Solanezumab | LY2062430 | Alzheimer's Disease (Discontinued) | Eli Lilly & Co. | Amyloid-Related | Immunotherapy (passive) | None |
| Thalidomide | Thalomid® | Alzheimer's Disease (Discontinued) | Celgene Corporation | Amyloid-Related, Inflammation | Small Molecule | |
| Umibecestat | CNP520, BACE Inhibitor |
Alzheimer's Disease (Discontinued) | Amgen, Inc., Novartis Pharmaceuticals Corporation | Amyloid-Related | Small Molecule | |
| Vanutide cridificar | ACC-001, PF-05236806 |
Alzheimer's Disease (Discontinued) | Janssen | Amyloid-Related | Immunotherapy (active) | None |
| Varoglutamstat | PQ912 | Alzheimer's Disease (Discontinued) | Probiodrug AG, Vivoryon Therapeutics N.V. | Amyloid-Related, Inflammation | Small Molecule | |
| Verubecestat | MK-8931, MK-8931-009 , BACE inhibitor |
Alzheimer's Disease (Discontinued) | Merck | Amyloid-Related | Small Molecule |