Therapeutics
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| Name | Synonyms | FDA Status | Company | Target Type | Therapy Type | Approved For |
|---|---|---|---|---|---|---|
| ABT-089 | Alzheimer's Disease (Discontinued) | Abbott Laboratories | Cholinergic System | Small Molecule | ||
| ABT-288 | Alzheimer's Disease (Discontinued) | AbbVie | Cholinergic System, Other Neurotransmitters | Small Molecule | ||
| ABT 418 | Alzheimer's Disease (Discontinued) | Cholinergic System | Small Molecule | None | ||
| AF 102B | cevimeline HCL, Evoxac™ |
Alzheimer's Disease (Discontinued) | SnowBrand Pharmaceuticals, Inc. | Cholinergic System | Small Molecule | Treatment of dry mouth in Sjogren's syndrome. |
| ALPHA-1062 | GLN-1062 , Memogain |
Alzheimer's Disease (Phase 3) | Alpha Cognition, Galantos Pharma | Cholinergic System | Small Molecule | |
| AQW051 | Alpha-7 nicotinic acetylcholine receptor agonist | Alzheimer's Disease (Inactive), Parkinson's Disease (Phase 2), Schizophrenia (Phase 2) | Novartis Pharmaceuticals Corporation | Cholinergic System | Small Molecule | |
| AZD1446 | TC-6683 | Alzheimer's Disease (Discontinued) | AstraZeneca, Targacept | Cholinergic System | Small Molecule | None |
| AZD3480 | ispronicline, TC-1734 |
Alzheimer's Disease (Inactive) | AstraZeneca, Targacept | Cholinergic System | Small Molecule | |
| BPN14770 | Alzheimer's Disease (Phase 2) | Shionogi Pharma, Tetra Therapeutics | Cholinergic System, Other | Small Molecule | ||
| Deep Brain Stimulation-nucleus basalis of Meynert | DBS-nbM | Alzheimer's Disease (Phase 2) | Cholinergic System, Other | Procedural Intervention | ||
| Donepezil | Aricept™, Donepezil hydrochloride, Eranz®, E 2020 |
Alzheimer's Disease (Approved), Dementia with Lewy Bodies (Inactive), Down's Syndrome (Inactive), Parkinson's Disease Dementia (Inactive) | Corium, Inc., Eisai Co., Ltd., Pfizer | Cholinergic System | Small Molecule | Alzheimer's Disease, Dementia with Lewy Bodies (Japan) |
| E2511 | Alzheimer's Disease (Phase 1) | Eisai Co., Ltd. | Cholinergic System | Small Molecule | ||
| Encenicline | EVP-6124 , MT-4666, α7-nAChR agonist |
Alzheimer's Disease (Discontinued), Schizophrenia (Discontinued) | FORUM Pharmaceuticals Inc., Mitsubishi Tanabe Pharma | Cholinergic System | Small Molecule | None |
| Eptastigmine | MF 201 | Alzheimer's Disease (Discontinued) | Mediolanum | Cholinergic System | Small Molecule | None |
| Galantamine | Razadyne™, Reminyl™, Nivalin® |
Alzheimer's Disease (Approved) | Janssen, Ortho-McNeil Pharmaceutical, Sanochemia Pharmazeutika, Shire, Takeda Pharmaceutical Company | Cholinergic System | Small Molecule | Mild to Moderate Alzheimer's disease |
| GSK239512 | Alzheimer's Disease (Discontinued) | GlaxoSmithKline (GSK) | Cholinergic System, Other Neurotransmitters | Small Molecule | ||
| HTL0018318 | Alzheimer's Disease (Inactive), Dementia with Lewy Bodies (Inactive) | Allergan plc, Sosei Heptares | Cholinergic System | Small Molecule | ||
| Huperzine A | ZT-1, DEBIO 9902 , Qian ceng ta, Cerebra capsule, Pharmassure Memorall capsule |
Alzheimer's Disease (Inactive) | Debiopharm Group™, Neuro-Hitech, Inc. | Cholinergic System | Small Molecule, Supplement, Dietary | None |
| KarXT | xanomeline-trospium | Alzheimer's Disease (Phase 3) | Karuna Therapeutics | Cholinergic System | Combination, Small Molecule | |
| Ladostigil | Ladostigil hemitartrate, TV3326 |
Mild Cognitive Impairment (Phase 2), Alzheimer's Disease (Discontinued) | Avraham Pharmaceuticals Ltd | Cholinergic System | Small Molecule | |
| LU25-109 | Alzheimer's Disease (Discontinued) | Cholinergic System | Small Molecule | None | ||
| Metrifonate | trichlorfon | Alzheimer's Disease (Discontinued) | Cholinergic System | Small Molecule | None | |
| Milameline | CI 979 | Alzheimer's Disease (Discontinued) | Aventis Pharmaceuticals, Inc. (was Hoechst) | Cholinergic System | Small Molecule | None |
| NA-831 | Traneurocin | Alzheimer's Disease (Phase 2) | Biomed Industries, NeuroActiva™ Inc. | Cholinergic System | Small Molecule | |
| Nefiracetam | Alzheimer's Disease (Discontinued) | Daiichi Sankyo Pharmaceuticals | Cholinergic System | Small Molecule | None | |
| Nelonicline | ABT-126 | Alzheimer's Disease (Discontinued), Schizophrenia (Inactive) | AbbVie | Cholinergic System | Small Molecule | |
| NSC001 | AF267B , NGX267, NI004 |
Alzheimer's Disease (Phase 1/2) | Neurimmune, TorreyPines Therapeutics, Inc. | Cholinergic System | Small Molecule | None |
| PF-06852231 | Alzheimer's Disease (Discontinued) | Pfizer | Cholinergic System | Small Molecule | ||
| Phenserine | Alzheimer's Disease (Inactive) | Annovis Bio, TorreyPines Therapeutics, Inc. | Cholinergic System | Small Molecule | ||
| Physostigmine Salicylate | Synapton | Alzheimer's Disease (Discontinued) | Forest Laboratories, Inc. | Cholinergic System | Small Molecule | |
| RG3487 | RO5313534, MEM 3454 |
Alzheimer's Disease (Inactive) | Cholinergic System | Small Molecule | ||
| Rivastigmine | Exelon™, Rivastigmine tartrate , Rivastach® Patch, Prometax®, SDZ ENA 713 |
Alzheimer's Disease (Approved), Parkinson's Disease Dementia (Approved) | Novartis Pharmaceuticals Corporation | Cholinergic System | Small Molecule | Mild to moderate Alzheimer’s disease and mild to moderate dementia related to Parkinson's disease |
| S 38093 | Alzheimer's Disease (Discontinued) | Servier | Cholinergic System, Other Neurotransmitters | Small Molecule | ||
| SUVN-G3031 | Samelisant, 17v |
Alzheimer's Disease (Phase 1) | Suven Life Sciences Ltd | Cholinergic System, Other Neurotransmitters | Small Molecule | |
| Tacrine | Cognex™ | Alzheimer's Disease (Approved) | Pfizer, Shionogi Pharma | Cholinergic System | Small Molecule | |
| Varenicline | Champix™, Chantix™, Varenicline tartrate, CP-526,555, Alpha4 beta2 nicotinic receptor agonist |
Alzheimer's Disease (Discontinued) | Pfizer | Cholinergic System | Small Molecule | Smoking cessation |