Therapeutics
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| Name | Synonyms | FDA Status | Company | Target Type | Therapy Type | Approved For |
|---|---|---|---|---|---|---|
| AAV2-BDNF | MCI due to AD (Phase 1), Alzheimer's Disease (Phase 1) | Other | DNA/RNA-based | |||
| ABBV-552 | Alzheimer's Disease (Phase 1) | AbbVie | Other | Small Molecule | ||
| ABBV-CLS-7262 | Fosigotifator, Fosigotifator sodium tromethamine |
Amyotrophic Lateral Sclerosis (Phase 2) | AbbVie, Calico Life Sciences LLC. | Other | Small Molecule | |
| ABT-384 | Alzheimer's Disease (Discontinued) | AbbVie | Other | Small Molecule | ||
| ABT-957 | Alicapistat | Alzheimer's Disease (Discontinued) | AbbVie | Other | Small Molecule | |
| ACD856 | Alzheimer's Disease (Phase 1) | AlzeCure Pharma AB | Other | Small Molecule | ||
| Acetyl-l-carnitine HCI | ALCAR | Alzheimer's Disease (Discontinued) | Sigma-Tau Pharmaceuticals | Other | Supplement, Dietary | |
| AIT-101 | Apilimod, apilimod dimesylate, STA-5326, LAM-002A |
Amyotrophic Lateral Sclerosis (Phase 2) | OrphAI Therapeutics | Other | Small Molecule | |
| AL101 | GSK-4527226 | Alzheimer's Disease (Phase 2) | Alector, GlaxoSmithKline (GSK) | Other | Immunotherapy (passive) | |
| Allopregnanolone | brexanolone, 3α-hydroxy-5α-pregnan-20-one, 3α,5α-tetrahydroprogesterone |
Alzheimer's Disease (Phase 2) | Other Neurotransmitters, Other | Small Molecule | ||
| Alpha-Tocopherol | Vitamin E | Alzheimer's Disease (Phase 3) | Other | Supplement, Dietary | ||
| Ambroxol | Ambrosan, Mucosolvan | Parkinson's Disease (Phase 2), Parkinson's Disease Dementia (Phase 2), Dementia with Lewy Bodies (Phase 2) | alpha-synuclein, Other | Small Molecule | ||
| ANX005 | Amyotrophic Lateral Sclerosis (Phase 2) | Annexon, Inc. | Inflammation, Other | Immunotherapy (passive) | ||
| Apabetalone | RVX208, RVX000222 |
MCI-VaD (Phase 3) | Resverlogix Corporation | Other | Small Molecule | |
| AR1001 | Alzheimer's Disease (Phase 3) | Aribio Co., Ltd. | Other | Small Molecule | ||
| Atuzaginstat | COR388 | Alzheimer's Disease (Discontinued) | Cortexyme, Inc., Quince Therapeutics | Other | Small Molecule | |
| AVB-101 | Frontotemporal Dementia (Phase 1/2) | AviadoBio | Other | DNA/RNA-based | ||
| Bemdaneprocel | BRT-DA01, MSK-DA01 |
Parkinson's Disease (Phase 1) | Bayer, BlueRock Therapeutics | Other Neurotransmitters, Other | Other | |
| Benfotiamine | S-benzoylthiamine-O-monophosphate, Vitamin B1, Thiamine |
Alzheimer's Disease (Phase 2) | Inflammation, Other | Supplement, Dietary | ||
| Bezisterim | NE3107, HE3286 |
Alzheimer's Disease (Phase 3), Parkinson's Disease (Phase 1/2) | BioVie Pharma | Inflammation, Other | Small Molecule | |
| BI 409306 | SUB 166499 | Alzheimer's Disease (Discontinued), Schizophrenia (Phase 2) | Boehringer Ingelheim | Other Neurotransmitters, Other | Small Molecule | |
| Bifidobacterium breve A1 | MCC1274, B. breve |
Mild Cognitive Impairment (Phase 2) | Morinaga Milk Industry Co., Ltd | Other | Supplement, Dietary | |
| BIIB078 | BIIB-078, IONIS-C9Rx |
Amyotrophic Lateral Sclerosis (Discontinued) | Biogen, IONIS Pharmaceuticals | Other | DNA/RNA-based | |
| BIIB094 | ION859, IONIS-BIIB7Rx |
Parkinson's Disease (Phase 1) | Biogen, IONIS Pharmaceuticals | Inflammation, Other | DNA/RNA-based | |
| BIIB100 | KPT-350 | Amyotrophic Lateral Sclerosis (Discontinued) | Biogen | Inflammation, Other | Small Molecule | |
| BIIB105 | ION541 | Amyotrophic Lateral Sclerosis (Discontinued) | Biogen, IONIS Pharmaceuticals | Other | DNA/RNA-based | |
| BIIB118 | PF-05251749 | Alzheimer's Disease (Phase 1), Parkinson's Disease (Phase 1) | Biogen | Other | Small Molecule | |
| Blarcamesine | Anavex 2-73 | Alzheimer's Disease (Phase 2/3), Parkinson's Disease Dementia (Phase 2), Parkinson's Disease (Phase 1) | Anavex Life Science Corp. | Other | Small Molecule | |
| Bosutinib | BOSULIF®, PF-5208763, SKI-606 |
Alzheimer's Disease (Phase 2), Dementia with Lewy Bodies (Phase 2) | Pfizer | Other | Small Molecule | Chronic myeloid leukemia |
| BPN14770 | Alzheimer's Disease (Phase 2) | Shionogi Pharma, Tetra Therapeutics | Cholinergic System, Other | Small Molecule | ||
| Bryostatin 1 | Alzheimer's Disease (Phase 2) | Synaptogenix, Inc. | Other | Other | ||
| Candesartan | Atacand, Candesartan cilexetil |
Mild Cognitive Impairment (Phase 2), Alzheimer's Disease (Phase 2) | AstraZeneca, Takeda Pharmaceutical Company | Other | Small Molecule | Hypertension, congestive heart failure |
| CDNF | cerebral dopamine neurotrophic factor | Parkinson's Disease (Phase 1/2) | Herantis Pharma Plc, Renishaw plc. | Other | Procedural Intervention, Other | |
| CERE-110 | Nerve Growth Factor gene therapy | Alzheimer's Disease (Discontinued) | Sangamo BioSciences, Inc. | Other | DNA/RNA-based | |
| Cerebrolysin | Alzheimer's Disease (Phase 2) | Ebewe Pharmaceutical | Other | Other | ||
| CHF 5074 | Mild Cognitive Impairment (Phase 2), Alzheimer's Disease (Inactive) | CereSpir™ Incorporated, Chiesi Pharmaceuticals Inc. | Amyloid-Related, Inflammation, Other | Small Molecule | ||
| Circadin | Alzheimer's Disease (Phase 2) | Neurim Pharmaceuticals Ltd. | Other | Small Molecule | Insomnia | |
| CNM-Au8 | Gold nanocrystals | Parkinson's Disease (Phase 2), Amyotrophic Lateral Sclerosis (Phase 2/3) | Clene Nanomedicine, Inc. | Metals, Other | Other | |
| Cocoa Flavanols | Mild Cognitive Impairment (Not Regulated) | Inflammation, Other | Supplement, Dietary | |||
| COGNIShunt™ | Alzheimer's Disease (Inactive) | Other | Procedural Intervention | None | ||
| Curcumin | diferuloylmethane, Longvida™ |
Alzheimer's Disease (Phase 2) | Verdure Sciences | Other, Unknown | Supplement, Dietary | None |
| Dapagliflozin | Farxiga, Forxiga, BMS 512148 |
Alzheimer's Disease (Phase 1/2) | AstraZeneca, Bristol-Myers Squibb | Other | Small Molecule | |
| Dapsone | Avlosulfon, Diaminodiphenylsulfone, DDS |
Alzheimer's Disease (Inactive) | Immune Network Ltd. | Other | Small Molecule | Leprosy, malaria, some bacterial skin infections |
| Dasatinib + Quercetin | Alzheimer's Disease (Phase 1/2) | Tau, Other | Combination, Small Molecule, Supplement, Dietary | |||
| Dayvigo | Lemborexant, E2006 |
Alzheimer's Disease (Phase 2) | Eisai Co., Ltd. | Other | Small Molecule | Insomnia |
| Deep Brain Stimulation-nucleus basalis of Meynert | DBS-nbM | Alzheimer's Disease (Phase 2) | Cholinergic System, Other | Procedural Intervention | ||
| Dexpramipexole | R-pramipexole, RPPX, KNS-760704 , BIIB 050 |
Alzheimer's Disease (Phase 2), Amyotrophic Lateral Sclerosis (Discontinued) | Biogen, Knopp Biosciences LLC, Virginia Commonwealth University | Other Neurotransmitters, Other | Small Molecule | |
| DNL151 | BIIB122 | Parkinson's Disease (Phase 2) | Biogen, Denali Therapeutics Inc. | Inflammation, Other | Small Molecule | |
| DNL201 | Parkinson's Disease (Inactive) | Biogen, Denali Therapeutics Inc. | Inflammation, Other | Small Molecule | ||
| DNL343 | Amyotrophic Lateral Sclerosis (Phase 2/3) | Denali Therapeutics Inc. | Other | Small Molecule | ||
| DNL593 | PTV:PGRN, TAK-594 |
Frontotemporal Dementia (Phase 1/2) | Denali Therapeutics Inc., Takeda Pharmaceutical Company | Other | Other | |
| Docosahexaenoic acid (DHA) | Omega-3 fatty acid | Alzheimer's Disease (Phase 4) | Martek Biosciences Corporation, NeuroBioPharm, Inc. | Other | Supplement, Dietary | |
| Edaravone | MCI-186, Radicava®, Radicut®, MT-1186, FAB122 |
Amyotrophic Lateral Sclerosis (Phase 4) | Mitsubishi Tanabe Pharma | Other | Small Molecule | Amyotrophic Lateral Sclerosis |
| Edonerpic | T-817 MA, T 817 | Alzheimer's Disease (Discontinued) | Toyama Chemical Co., Ltd. | Other, Unknown | Small Molecule | |
| EHT 0202 | Etazolate | Alzheimer's Disease (Phase 2) | ExonHit Therapeutics | Other | Small Molecule | None |
| Empagliflozin | Jardiance, BI-10773 |
Alzheimer's Disease (Phase 1) | Boehringer Ingelheim, Eli Lilly & Co. | Other | Small Molecule | Type 2 Diabetes, Cardiovascular disease |
| Emrusolmin | Anle138b, TEV-56286 |
Parkinson's Disease (Phase 1/2), Multiple System Atrophy (Phase 2) | MODAG GmbH, Teva | Tau, alpha-synuclein, Other | Small Molecule | |
| Emtricitabine | Alzheimer's Disease (Phase 1) | Gilead Sciences, Inc. | Other | Small Molecule | ||
| Engensis | VM202, pCK-HGF-X7, NL003, hepatocyte growth factor | Amyotrophic Lateral Sclerosis (Phase 2) | Helixmith | Other | DNA/RNA-based | |
| Epigallocatechin Gallate (EGCG) | Sunphenon EGCg | Alzheimer's Disease (Phase 2/3), Down's Syndrome (Phase 2), Multiple System Atrophy (Phase 3) | Taiyo International | Amyloid-Related, Inflammation, Other | Supplement, Dietary | |
| Estrogen | Premarin™ | Alzheimer's Disease (Discontinued) | Other | Other | Hormone Replacement Therapy | |
| Exenatide | Exendin-4, Byetta, Bydureon |
Alzheimer's Disease (Inactive), Parkinson's Disease (Phase 3) | AstraZeneca, Eli Lilly & Co. | Other | Small Molecule | Diabetes mellitus in US |
| Ezeprogind | AZP2006 , AZP-2006 |
Progressive Supranuclear Palsy (Phase 2) | AlzProtect | Tau, Inflammation, Other | Small Molecule | |
| Focused Ultrasound – Blood-Brain Barrier | FUS-BBB, MRgFUS, MRI-Guided Focused Ultrasound, FUS+MB |
Alzheimer's Disease (Phase 1), Amyotrophic Lateral Sclerosis (Phase 1), Mild Cognitive Impairment (Phase 1), Parkinson's Disease (Phase 1) | Amyloid-Related, Other | Procedural Intervention | ||
| Fosgonimeton | ATH-1017, NDX-1017 |
Alzheimer's Disease (Discontinued), Dementia with Lewy Bodies (Discontinued), Parkinson's Disease Dementia (Discontinued) | Athira Pharma | Other | Small Molecule | |
| FRM-0334 | EVP-0334 | Frontotemporal Dementia (Discontinued) | FORUM Pharmaceuticals Inc. | Other | Small Molecule | |
| G-CSF | Filgrastim | Alzheimer's Disease (Phase 2) | Other | Small Molecule | Neutropenia in US | |
| GRF6019 | Alzheimer's Disease (Phase 2) | Alkahest, Inc., Grifols Biologicals Inc. | Inflammation, Other, Unknown | Other | ||
| GRF6021 | AKST/GRF6021 | Parkinson's Disease Dementia (Phase 2) | Alkahest, Inc., Grifols Biologicals Inc. | Inflammation, Other, Unknown | Other | |
| GV1001 | RIAVAXTM, Tertomotide | Alzheimer's Disease (Phase 3) | GemVax & KAEL Bio | Other | Immunotherapy (active) | Pancreatic cancer (Korea) |
| IBC-Ab002 | Alzheimer's Disease (Phase 1) | ImmunoBrain Checkpoint | Amyloid-Related, Inflammation, Other | Immunotherapy (passive) | ||
| Idebenone | Catena, Sovrima |
Alzheimer's Disease (Discontinued) | Takeda Pharmaceutical Company | Other | Small Molecule | None |
| Intranasal oxytocin | Syntocinon, Pitocin |
Frontotemporal Dementia (Phase 2) | Other | Other | ||
| Irsenontrine | E2027 | Dementia with Lewy Bodies (Phase 2) | Eisai Co., Ltd. | Other | Small Molecule | |
| Ketasyn | Axona, Caprylic Acid, AC-1202 |
Alzheimer's Disease (Phase 4) | Cerecin Pte. Ltd. | Other | Supplement, Dietary | |
| kMCT-ONS | medium chain triglyceride-based ketogenic oral nutritional supplement, kMCT | Alzheimer's Disease (Not Regulated) | Nestlé Health Science | Other | Supplement, Dietary | |
| Latozinemab | AL001, GSK4527223 |
Frontotemporal Dementia (Phase 3), Amyotrophic Lateral Sclerosis (Inactive) | Alector, GlaxoSmithKline (GSK) | Other | Immunotherapy (passive) | |
| Leuprolide | Leuprolide acetate , Lupron Depot, Eligard |
Alzheimer's Disease (Phase 2) | Tolmar Pharmaceuticals, Inc. | Other | Other | Advanced prostate cancer |
| Levetiracetam | Keppra | Alzheimer's Disease (Phase 2), Parkinson's Disease (Discontinued) | UCB S.A. | Amyloid-Related, Other | Small Molecule | Epilepsy and Partial Seizures in U.S., European Union, plus about 20 other countries |
| Linopirdine | DuP996 | Alzheimer's Disease (Discontinued) | Other | Small Molecule | None | |
| Liraglutide | Victoza™, Saxenda™ |
Alzheimer's Disease (Phase 2), Parkinson's Disease (Phase 2) | Novo Nordisk A/S | Other | Other | Diabetes, weight loss |
| Lixisenatide | Adlyxin, Lyxumia |
Parkinson's Disease (Phase 2) | Sanofi | Other | Other | Type 2 diabetes |
| LM11A-31-BHS | LM11A-31 | Alzheimer's Disease (Phase 2) | PharmatrophiX | Other | Small Molecule | |
| Lomecel-B | mesenchymal stem cells | Alzheimer's Disease (Phase 2) | Longeveron | Inflammation, Other | Other | |
| Losartan | Cozaar®, MK0954 |
Alzheimer's Disease (Phase 2) | Merck | Other | Small Molecule | Hypertension, diabetic neuropathy |
| LTI-291 | Parkinson's Disease (Phase 2) | Lysosomal Therapeutics Inc. | Other | Small Molecule | ||
| Lu AF88434 | Mild Cognitive Impairment (Discontinued) | Lundbeck | Other | Small Molecule | ||
| LY3884961 | PR001, PR001A |
Parkinson's Disease (Phase 1/2) | Eli Lilly & Co., Prevail Therapeutics | Other | DNA/RNA-based | |
| LY3884963 | PR006 | Frontotemporal Dementia (Phase 1/2) | Eli Lilly & Co., Prevail Therapeutics | Other | DNA/RNA-based | |
| Masitinib | Masivet, Kinavet, AB1010, Masitinib mesylate |
Alzheimer's Disease (Phase 3), Amyotrophic Lateral Sclerosis (Phase 3) | AB Science | Other | Small Molecule | |
| Melatonin | Alzheimer's Disease (Phase 2) | Other | Supplement, Dietary | None | ||
| MEM 1003 | BAY Z 4406 | Alzheimer's Disease (Discontinued), Mild Cognitive Impairment (Discontinued), Vascular Dementia (Discontinued), Bipolar Disorder (Discontinued) | Memory Pharmaceuticals Corporation | Other | Small Molecule | None |
| MemorEM Transcranial Electromagnetic Treatment | TEMT | Alzheimer's Disease (Phase 1) | NeuroEM Therapeutics, Inc. | Amyloid-Related, Other | Procedural Intervention | |
| Metformin | Glucophage, Glucophage XR |
Alzheimer's Disease (Phase 2/3) | Other | Small Molecule | Type 2 Diabetes | |
| Minocycline | Solodyn, Arestin, Minocin, Dynacin |
Alzheimer's Disease (Discontinued) | Other | Small Molecule | ||
| MSDC-0160 | Mitoglitazone | Alzheimer's Disease (Phase 2) | Metabolic Solutions Development Company | Other | Small Molecule | |
| Multivitamin-mineral Supplement | Centrum Silver | Mild Cognitive Impairment (Not Regulated) | Pfizer | Other | Supplement, Dietary | |
| MW150 | MW01-18-150SRM | Alzheimer's Disease (Phase 2) | Neurokine Therapeutics | Inflammation, Other | Small Molecule | |
| Nasal Insulin | Detemir, Levemir, Humulin, Novolin, glulisine |
Alzheimer's Disease (Phase 2/3), Mild Cognitive Impairment (Phase 2), Parkinson's Disease (Phase 2), Multiple System Atrophy (Phase 2) | Amyloid-Related, Other | Small Molecule, Other | Diabetes | |
| NeuroAD | Repetitive Transcranial Magnetic Stimulation , rTMS-Cog |
Alzheimer's Disease (Rejected) | Neuronix Ltd | Other | Procedural Intervention | |
| NIC5-15 | Pinitol, D-Pinitol |
Alzheimer's Disease (Phase 2) | Humanetics Pharmaceuticals Corporation | Amyloid-Related, Other | Small Molecule, Supplement, Dietary | |
| Nicotinamide Riboside | Niagen, NR, Nicotinamide, Vitamin B3 |
Alzheimer's Disease (Phase 1), Parkinson's Disease (Phase 2), Mild Cognitive Impairment (Phase 1/2) | ChromaDex, Others | Other | Supplement, Dietary | |
| Nilotinib | Tasigna, AMN107 |
Parkinson's Disease (Phase 2), Dementia with Lewy Bodies (Phase 2), Alzheimer's Disease (Phase 3) | KeifeRx | Other | Small Molecule | Chronic myeloid leukemia |
| Nilvadipine | Nilvad, Nivadil, ARC029 |
Alzheimer's Disease (Inactive) | Archer Pharmaceuticals, Inc. | Other | Small Molecule | |
| NPT520-34 | Amyotrophic Lateral Sclerosis (Phase 1), Parkinson's Disease (Phase 1) | Neuropore Therapies, Inc. | alpha-synuclein, Inflammation, Other | Small Molecule | ||
| NTRX-07 | MDA7 | Alzheimer's Disease (Phase 1) | NeuroTherapia, Inc. | Inflammation, Other | Small Molecule | |
| NurOwn™ | MSC-NTF Cells, debamestrocel , Neurotrophic factors-secreting Mesenchymal Stromal Cells |
Amyotrophic Lateral Sclerosis (Phase 3) | BrainStorm Cell Therapeutics, Inc. | Other | Other | |
| NX210c | HWSGWSS[CSRSC]GOH (brackets represent the disulfide bond) | Amyotrophic Lateral Sclerosis (Phase 2), Parkinson's Disease (Phase 1) | Axoltis Pharma | Other | Small Molecule | |
| PBFT02 | Frontotemporal Dementia (Phase 1/2) | Passage Bio | Other | DNA/RNA-based | ||
| Pioglitazone | AD4833, Actos®, Glustin™, Piozone® |
Mild Cognitive Impairment (Phase 3) | Takeda Pharmaceutical Company, Zinfandel Pharmaceuticals Inc. | Inflammation, Other | Small Molecule | Type 2 diabetes mellitus |
| Piromelatine | Neu-P11 | Alzheimer's Disease (Phase 2) | Neurim Pharmaceuticals Ltd. | Other Neurotransmitters, Other | Small Molecule | |
| Pridopidine | ACR16, TV-7820, Huntexil, ASP2314 |
Amyotrophic Lateral Sclerosis (Phase 2/3), Huntington's Disease (Phase 3), Parkinson's Disease (Inactive) | Prilenia Therapeutics | Other | Small Molecule | |
| PRX-03140 | Potassium salt | Alzheimer's Disease (Inactive) | Epix Pharmaceuticals | Other | Small Molecule | |
| PU-AD | PU-HZ151, icapamespib |
Alzheimer's Disease (Phase 2) | Samus Therapeutics | Other | Small Molecule | |
| QALSODY™ | Tofersen, BIIB067, Ionis-SOD1Rx , ASO1 |
Amyotrophic Lateral Sclerosis (Approved) | Biogen, IONIS Pharmaceuticals | Other | DNA/RNA-based | ALS |
| QRL-101 | QRA-244 | Amyotrophic Lateral Sclerosis (Phase 1) | QurAlis Corporation | Other | Small Molecule | |
| QRL-201 | Amyotrophic Lateral Sclerosis (Phase 1) | QurAlis Corporation | Other | DNA/RNA-based | ||
| Relyvrio | Albrioza, AMX0035 |
Amyotrophic Lateral Sclerosis (Approved), Alzheimer's Disease (Phase 2) | Amylyx Pharmaceuticals Inc | Other | Combination, Small Molecule | ALS |
| Resveratrol | trans-3,4',5-trihydroxystilbene | Alzheimer's Disease (Phase 3), Mild Cognitive Impairment (Phase 4) | Other | Small Molecule, Supplement, Dietary | ||
| Rilapladib | SB-659032 | Alzheimer's Disease (Discontinued) | GlaxoSmithKline (GSK) | Other | Small Molecule | |
| Riluzole | Rilutek®, RP 54274 |
Alzheimer's Disease (Phase 2), Parkinson's Disease (Discontinued), Amyotrophic Lateral Sclerosis (Approved), Huntington's Disease (Discontinued) | Sanofi | Other Neurotransmitters, Other | Small Molecule | Amyotrophic Lateral Sclerosis in many countries |
| Rosiglitazone | Rosiglitazone maleate, Avandia |
Alzheimer's Disease (Discontinued) | GlaxoSmithKline (GSK) | Other | Small Molecule | |
| S-Equol | Aus-131 | Alzheimer's Disease (Phase 1) | Ausio Pharmaceuticals, LLC | Other | Small Molecule | |
| SAR110894D | Alzheimer's Disease (Phase 2) | Sanofi | Other | Small Molecule | ||
| Saracatinib | AZD0530 | Alzheimer's Disease (Discontinued), Parkinson's Disease (Phase 1) | AstraZeneca | Other | Small Molecule | |
| Sargramostim | GM-CSF Leukine , Leukine® |
Alzheimer's Disease (Phase 2), Parkinson's Disease (Phase 1) | Genzyme, Partner Therapeutics, Inc., Sanofi | Inflammation, Other, Unknown | Other | Bone Marrow Stimulation |
| Seltorexant | JNJ-42847922, MIN-202 |
Alzheimer's Disease (Phase 2) | Janssen | Other | Small Molecule | |
| Semaglutide | Ozempic, Wegovy, Rybelsus |
Alzheimer's Disease (Phase 3), Parkinson's Disease (Phase 2) | Novo Nordisk A/S | Other | Other | Type 2 Diabetes, Obesity, Protection against myocardial infarction and stroke |
| Sembragiline | RO4602522, RG1577 |
Alzheimer's Disease (Discontinued) | Evotech AG | Other Neurotransmitters, Other | Small Molecule | |
| Sensory Stimulation Systems | GENUS, Gamma entrainment using sensory stimuli, GammaSense Stimulation |
Alzheimer's Disease (Phase 3), Parkinson's Disease (Not Regulated), Down's Syndrome (Not Regulated) | Cognito Therapeutics, Inc. | Amyloid-Related, Inflammation, Other | Combination, Procedural Intervention | |
| Souvenaid | Fortasyn Connect | Alzheimer's Disease (Not Regulated) | Nutricia | Other | Supplement, Dietary | |
| Suvorexant | Belsomra, MK-4305 |
Alzheimer's Disease (Approved) | Merck | Other | Small Molecule | Insomnia, Insomnia in mild to moderate Alzheimer's disease |
| T3D-959 | DB959 | Alzheimer's Disease (Phase 2) | T3D Therapeutics, Inc. | Other | Small Molecule | |
| Telmisartan | Micardis | Alzheimer's Disease (Phase 2) | Boehringer Ingelheim | Other | Small Molecule | Hypertension |
| Tricaprilin | AC-1204 , Caprylic triglyceride, AC-SD-03, CER-000, AC-OLE-O1-VA |
Alzheimer's Disease (Phase 3) | Cerecin Pte. Ltd. | Other | Supplement, Dietary, Other | None |
| TW001 | FNP122, FAB122, oral edaravone |
Alzheimer's Disease (Phase 2), Amyotrophic Lateral Sclerosis (Phase 3) | Treeway B.V. | Other | Small Molecule | |
| Ulefnersen | ION363, Jacifusen |
Amyotrophic Lateral Sclerosis (Phase 3) | IONIS Pharmaceuticals | Other | DNA/RNA-based | |
| Valacyclovir | Valtrex, Valaciclovir, 256U87 |
Alzheimer's Disease (Phase 2) | GlaxoSmithKline (GSK) | Other | Small Molecule | Herpes virus outbreaks |
| Vascepa | Icosapent ethyl (IPE), Ethyl eicosapentaenoic acid (E-EPA), AMR101, Miraxion |
Alzheimer's Disease (Phase 2/3) | Other | Small Molecule | Severe hypertriglyceridemia, and to lower risk of cardiovascular events in people with elevated triglycerides | |
| Venglustat | Ibiglustat, GZ/SAR402671, Genz-682452 |
Parkinson's Disease (Inactive) | Genzyme, Sanofi | alpha-synuclein, Other | Small Molecule | |
| Verdiperstat | AZD3241, BHV-3241 |
Motor Neuron Disease (Discontinued), Multiple System Atrophy (Discontinued), Primary Progressive Aphasia (Phase 1) | AstraZeneca, Biohaven Pharmaceuticals | Inflammation, Other | Small Molecule | |
| VGL101 | Iluzanebart | Adult-onset Leukoencephalopathy with Axonal Spheroids and Pigmented Glia (Phase 2) | Vigil Neuroscience, Inc. | Inflammation, Other | Immunotherapy (passive) | |
| Vodobatinib | K0706, SCC-138, SCO-088 |
Parkinson's Disease (Phase 2), Dementia with Lewy Bodies (Phase 2) | Sun Pharma Advanced Research Company Ltd. | Other | Small Molecule | |
| WVE-004 | Frontotemporal Dementia (Discontinued), Amyotrophic Lateral Sclerosis (Discontinued) | Wave Life Sciences USA, Inc. | Other | DNA/RNA-based | ||
| Xaliproden | SR 57746A | Alzheimer's Disease (Discontinued) | Sanofi | Other Neurotransmitters, Other | Small Molecule | |
| Xanamem | UE 2343 | Alzheimer's Disease (Phase 2) | Actinogen Medical | Other | Small Molecule | |
| Young Plasma | Progressive Supranuclear Palsy (Inactive), Alzheimer's Disease (Inactive) | Alkahest, Inc., Grifols Biologicals Inc. | Inflammation, Other, Unknown | Other | ||
| YTX-7739 | Parkinson's Disease (Phase 1) | Yumanity Therapeutics | Other | Small Molecule |