Mistakes Prompt Retraction of Controversial Paper, and Publication Ban
The Journal of Neuroscience retracted a paper that claimed Aβ does not accumulate inside neurons, and temporarily banished its senior authors.
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Brexit Could Threaten Neurodegenerative Disease Research in Europe
The United Kingdom’s exit from the European Union will likely slash funding, impede collaborations, and slow the pace of science.
U.S. Study Says Lithium in Tap Water Does Not Fend Off Dementia
Prior evidence for protective effect evaporates after adjustment for demographic differences in high- and low-lithium communities.
Lymphatic Brain Drain Withers in Aging, Worsens Disease
Aging lymphatic vessels in the meninges hinder waste clearance from the brain and exacerbate Aβ build-up.
CryoEM γ-Secretase Structures Nail APP, Notch Binding
First look at substrate interactions reveals similarities but some surprises.
Closing the Book on NSAIDs for Alzheimer’s Prevention
The latest effort to determine if a non-steroidal anti-inflammatory drug protects against Alzheimer’s posted negative results. Time to abandon the approach?
Anatomy News Flash: Brain Drains Lymphatic Fluid Through Its Base
In mice, the back of the brain, near the neck, contains lymphatic vessels that are specialized to take up cerebrospinal fluid and deliver it to cervical lymph nodes.
A Central Role for Prion Protein in Neurodegeneration?
Researchers implicate PrP in the toxicity of Aβ, tau, and α-synuclein oligomers in several neurodegenerative diseases.
Blunt Instruments: α-Synuclein Antibodies Poorly Distinguish Forms
A survey of 16 purported conformation-specific antibodies found that most bound nearly equally well to oligomers and fibrils, and weakly to monomers.
New Data Questions Herpes-Alzheimer’s Connection
A large multinational epidemiology study finds only small and inconsistent associations.
Microglia Build Plaques to Protect the Brain
Instead of chewing up and disposing of the amyloid they ingest, microglia appear to compact it, then spit it back out as dense-core plaque.
On Donanemab, Plaques Plummet. Off Donanemab, They Stay Away
Data from a Phase 2 trial also suggested that when amyloid dropped in treated brain, plasma p-tau217 followed suit. Using a CAMD progression model, Lilly claims the biomarker responses correlated with slower decline.
In Side-by-Side Test of 8 Blood Aβ Assays, Mass Spec Shines
In a collaborative tour de force, scientists for the first time compared eight Aβ assays in the same plasma samples. Mass-spectrometry assays more accurately picked up brain amyloid than did most immunoassays, but one fully automated immunoassay was on par.
Could Restoring Deep Sleep by Jolting the Brain Ward Off Alzheimer’s?
In mouse models, a sluggish thalamic reticular nucleus shortens slow-wave sleep. In one model, activating this brain area lengthened the mice's slumber while also reducing their plaque loads.
Like GWAS, BWAS Need Thousands of Participants
To find true brain-behavior correlations, a brain-wide association study needs orders of magnitude more people than the dozens typically used in neuroimaging research.
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